OBJECTIVE: The objective of this study was to evaluate the application of platelet-rich fibrin (PRF) into a peri-implant defect in vivo. STUDY DESIGN: Eight New Zealand white rabbits were used for this study. Two peri-implants with defects sized 3.0 × 5.0 mm (width × length) were prepared after drilling to host the dental implant in the tibia. Subsequently, the 2 dental implants were installed (diameter, 3.0 mm and length, 8.0 mm). In the experimental group, PRF was applied into the bony defect. In the control group, the peri-implant defect was left unfilled. The animals were humanely killed 8 weeks after implantation and histomorphometric analysis was done. RESULTS: In the histomorphometric analysis, mean new bone formation was 29.30% ± 7.50% in the experimental group and 11.06% ± 8.94% in the control group (P = .020). Mean bone-to-implant contact was 39.43% ± 7.39% in the experimental group and 17.11% ± 8.12% in the control group (P = .006). CONCLUSIONS: In the animal model, peri-implant defect sized 3.0 × 5.0 mm (width × length) was successfully repaired by the application of PRF alone. Copyright Â
OBJECTIVE: The objective of this study was to evaluate the application of platelet-rich fibrin (PRF) into a peri-implant defect in vivo. STUDY DESIGN: Eight New Zealand white rabbits were used for this study. Two peri-implants with defects sized 3.0 × 5.0 mm (width × length) were prepared after drilling to host the dental implant in the tibia. Subsequently, the 2 dental implants were installed (diameter, 3.0 mm and length, 8.0 mm). In the experimental group, PRF was applied into the bony defect. In the control group, the peri-implant defect was left unfilled. The animals were humanely killed 8 weeks after implantation and histomorphometric analysis was done. RESULTS: In the histomorphometric analysis, mean new bone formation was 29.30% ± 7.50% in the experimental group and 11.06% ± 8.94% in the control group (P = .020). Mean bone-to-implant contact was 39.43% ± 7.39% in the experimental group and 17.11% ± 8.12% in the control group (P = .006). CONCLUSIONS: In the animal model, peri-implant defect sized 3.0 × 5.0 mm (width × length) was successfully repaired by the application of PRF alone. Copyright Â
Authors: Fernanda Faot; Sanne Deprez; Katleen Vandamme; Germana V Camargos; Nelson Pinto; Jasper Wouters; Joost van den Oord; Marc Quirynen; Joke Duyck Journal: Sci Rep Date: 2017-04-12 Impact factor: 4.379
Authors: Ana B Castro; Nastaran Meschi; Andy Temmerman; Nelson Pinto; Paul Lambrechts; Wim Teughels; Marc Quirynen Journal: J Clin Periodontol Date: 2017-01-10 Impact factor: 8.728