Literature DB >> 22676911

TRAIL as biomarker and potential therapeutic tool for cardiovascular diseases.

Stella Bernardi1, Daniela Milani, Bruno Fabris, Paola Secchiero, Giorgio Zauli.   

Abstract

This review focuses on TNF-related apoptosis-inducing ligand (TRAIL), also called Apo2 ligand, a protein belonging to the TNF superfamily. TRAIL can be found either in its transmembrane or circulating form, and its mostly studied peripheral effect is the induction of cellular apoptosis. Here, we discuss the evidences supporting the use of TRAIL as biomarker of cardiovascular diseases as well as the evidences showing the potential beneficial therapeutic effects of TRAIL on cardiovascular diseases and diabetes.

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Year:  2012        PMID： 22676911     DOI： 10.2174/138945012802002357

Source DB:  PubMed          Journal:  Curr Drug Targets        ISSN： 1389-4501            Impact factor:   3.465


  6 in total

Review 1.  TRAIL modulates the immune system and protects against the development of diabetes.

Authors:  Fleur Bossi; Stella Bernardi; Giorgio Zauli; Paola Secchiero; Bruno Fabris
Journal:  J Immunol Res       Date:  2015-02-18       Impact factor: 4.818

2.  Expression of osteoprotegerin and its ligands, RANKL and TRAIL, in rheumatoid arthritis.

Authors:  Sara Remuzgo-Martínez; Fernanda Genre; Raquel López-Mejías; Begoña Ubilla; Verónica Mijares; Trinitario Pina; Alfonso Corrales; Ricardo Blanco; Javier Martín; Javier Llorca; Miguel A González-Gay
Journal:  Sci Rep       Date:  2016-07-12       Impact factor: 4.379

3.  TRAIL/DR5 signaling promotes macrophage foam cell formation by modulating scavenger receptor expression.

Authors:  Fang Fang Liu; Xiao Wu; Yun Zhang; Yan Wang; Fan Jiang
Journal:  PLoS One       Date:  2014-01-22       Impact factor: 3.240

4.  Patients with ankylosing spondylitis and low disease activity because of anti-TNF-alpha therapy have higher TRAIL levels than controls: a potential compensatory effect.

Authors:  Fernanda Genre; Raquel López-Mejías; Javier Rueda-Gotor; José A Miranda-Filloy; Begoña Ubilla; Beatriz Carnero-López; Natalia Palmou-Fontana; Inés Gómez-Acebo; Ricardo Blanco; Trinitario Pina; Rodrigo Ochoa; Carlos González-Juanatey; Javier Llorca; Miguel A González-Gay
Journal:  Mediators Inflamm       Date:  2014-05-21       Impact factor: 4.711

5.  Microgravity Induction of TRAIL Expression in Preosteoclast Cells Enhances Osteoclast Differentiation.

Authors:  Yuvaraj Sambandam; Kelsey L Baird; Maxwell Stroebel; Emily Kowal; Sundaravadivel Balasubramanian; Sakamuri V Reddy
Journal:  Sci Rep       Date:  2016-05-04       Impact factor: 4.379

6.  Soluble TRAIL Concentration in Serum Is Elevated in People with Hypercholesterolemia.

Authors:  Wen Cheng; Fangfang Liu; Zhe Wang; Yun Zhang; Yu-Xia Zhao; Qunye Zhang; Fan Jiang
Journal:  PLoS One       Date:  2015-12-03       Impact factor: 3.240
  6 in total

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