Literature DB >> 22675011

Statin resistant dyslipidemia in a patient treated with amiodarone.

Ahmad Al-Sarraf1, Min Li, Jiri Frohlich.   

Abstract

The authors describe a patient treated with amiodarone presented with high low-density lipoprotein cholesterol (LDL-C) levels who did not respond to treatment with a statin. Both amiodarone and amiodarone induced hypothyroidism influence the synthesis of LDL-receptor which may explain the lack of effect of statin. This was confirmed by normalisation of LDL-C upon discontinuation of amiodarone and treatment with thyroxine.

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Year:  2011        PMID： 22675011      PMCID： PMC3207754          DOI： 10.1136/bcr.08.2011.4620

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN： 1757-790X


  10 in total

Review 1.  Hypothyroidism and atherosclerosis.

Authors:  Anne R Cappola; Paul W Ladenson
Journal:  J Clin Endocrinol Metab       Date:  2003-06       Impact factor: 5.958

2.  Obesity : impact on cardiovascular disease

Authors: 
Journal:  Circulation       Date:  1998-10-06       Impact factor: 29.690

Review 3.  Structure and regulation of the LDL-receptor and its gene.

Authors:  A K Soutar; B L Knight
Journal:  Br Med Bull       Date:  1990-10       Impact factor: 4.291

Review 4.  Acquired hyperlipidemia (secondary dyslipoproteinemias).

Authors:  A Chait; J D Brunzell
Journal:  Endocrinol Metab Clin North Am       Date:  1990-06       Impact factor: 4.741

5.  Hyperhomocysteinemia and hypercholesterolemia associated with hypothyroidism in the third US National Health and Nutrition Examination Survey.

Authors:  M S Morris; A G Bostom; P F Jacques; J Selhub; I H Rosenberg
Journal:  Atherosclerosis       Date:  2001-03       Impact factor: 5.162

6.  Effects of triiodothyronine and amiodarone on the promoter of the human LDL receptor gene.

Authors:  O Bakker; F Hudig; S Meijssen; W M Wiersinga
Journal:  Biochem Biophys Res Commun       Date:  1998-08-19       Impact factor: 3.575

7.  Cholesterol metabolism in hypothyroidism and hyperthyroidism in man.

Authors:  J J Abrams; S M Grundy
Journal:  J Lipid Res       Date:  1981-02       Impact factor: 5.922

8.  Regulation of low-density-lipoprotein metabolism in the rat.

Authors:  S Bhattacharya; S Balasubramaniam; L A Simons
Journal:  Biochem J       Date:  1986-03-01       Impact factor: 3.857

9.  Amiodarone-induced hypercholesterolemia is associated with a decrease in liver LDL receptor mRNA.

Authors:  F Hudig; O Bakker; W M Wiersinga
Journal:  FEBS Lett       Date:  1994-03-14       Impact factor: 4.124

10.  Amiodarone decreases gene expression of low-density lipoprotein receptor at both the mRNA and the protein level.

Authors:  F Hudig; O Bakker; W M Wiersinga
Journal:  Metabolism       Date:  1998-09       Impact factor: 8.694
  10 in total
  1 in total

1.  ABCB1 C3435T polymorphism and the lipid-lowering response in hypercholesterolemic patients on statins: a meta-analysis.

Authors:  Jia Su; Hongyu Xu; Jun Yang; Qinglin Yu; Shujun Yang; Jianjiang Zhang; Qi Yao; Yunyun Zhu; Yuan Luo; Lindan Ji; Yibo Zheng; Jingbo Yu
Journal:  Lipids Health Dis       Date:  2015-10-06       Impact factor: 3.876
  1 in total

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