Literature DB >> 22674846

Continuous synthesis and purification by direct coupling of a flow reactor with simulated moving-bed chromatography.

Alexander G O'Brien1, Zoltán Horváth, François Lévesque, Ju Weon Lee, Andreas Seidel-Morgenstern, Peter H Seeberger.   

Abstract

Continuous synthesis meets continuous purification to produce pure products from crude reaction mixtures. In the nucleophilic aromatic substitution of 2,4-difluoronitrobenzene with morpholine the desired monosubstituted product can be continuously separated from the byproducts in a purity of over 99 % by coupling a flow reactor to a simulated moving bed (SMB) chromatography module.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Year:  2012        PMID： 22674846     DOI： 10.1002/anie.201202795

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  6 in total

1.  Rapid and efficient trifluoromethylation of aromatic and heteroaromatic compounds using potassium trifluoroacetate enabled by a flow system.

Authors:  Mao Chen; Stephen L Buchwald
Journal:  Angew Chem Int Ed Engl       Date:  2013-09-05       Impact factor: 15.336

2.  A systems approach towards an intelligent and self-controlling platform for integrated continuous reaction sequences.

Authors:  Richard J Ingham; Claudio Battilocchio; Daniel E Fitzpatrick; Eric Sliwinski; Joel M Hawkins; Steven V Ley
Journal:  Angew Chem Int Ed Engl       Date:  2014-11-05       Impact factor: 15.336

3.  Continuous Synthesis and Purification by Coupling a Multistep Flow Reaction with Centrifugal Partition Chromatography.

Authors:  Róbert Örkényi; János Éles; Ferenc Faigl; Péter Vincze; Anita Prechl; Zoltán Szakács; János Kóti; István Greiner
Journal:  Angew Chem Int Ed Engl       Date:  2017-06-19       Impact factor: 15.336

4.  Transetherification of 2,4-dimethoxynitrobenzene by aromatic nucleophilic substitution.

Authors:  Jiho Song; Hae Ju Kang; Jung Wuk Lee; Michelle A Wenas; Seung Hwarn Jeong; Taeho Lee; Kyungsoo Oh; Kyung Hoon Min
Journal:  PLoS One       Date:  2017-08-23       Impact factor: 3.240

5.  Synthesis of homo- and heteromultivalent carbohydrate-functionalized oligo(amidoamines) using novel glyco-building blocks.

Authors:  Felix Wojcik; Sinaida Lel; Alexander G O'Brien; Peter H Seeberger; Laura Hartmann
Journal:  Beilstein J Org Chem       Date:  2013-11-07       Impact factor: 2.883

6.  Integration of enabling methods for the automated flow preparation of piperazine-2-carboxamide.

Authors:  Richard J Ingham; Claudio Battilocchio; Joel M Hawkins; Steven V Ley
Journal:  Beilstein J Org Chem       Date:  2014-03-12       Impact factor: 2.883
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.