PURPOSE: The presence of both systemic and airway inflammation has been suggested in obstructive sleep apnea (OSA) by increased levels of inflammatory biomarkers in the circulation and respiratory specimens. We aimed to investigate the relationship between systemic and airway inflammation in OSA. METHODS: This study was conducted by simultaneously measuring various biomarkers both in serum and induced sputum of 43 patients. We compared the relationships of these biomarker levels with polysomnographic data and obesity measurements and also investigated their interrelationships between systemic and local compartments. We also assessed the relation of inflammatory markers with proximal airway resistance measured by impulse oscillometry. RESULTS: In multiple regression analyses, each measured serum biomarker [leptin, interleukin-6 (IL-6), IL-8, tumor necrosis factor-α (TNF-α), and vascular endothelial growth factor (VEGF)] significantly correlated with waist circumference or fat area determined by computed tomography. In contrast, regarding airway inflammation, sputum IL-6, IL-8, TNF-α, and VEGF significantly correlated with OSA severity as indicated by the respiratory disturbance index or oxygen desaturation indices. Sputum IL-6, IL-8, TNF-α, and VEGF were significantly related to sputum neutrophil number, and sputum IL-8 and TNF-α were related to proximal airway resistance independently of body mass index. There were no significant interrelationships between the same biomarkers in serum and induced sputum. CONCLUSIONS: Systemic and airway inflammation in OSA might be differently regulated by OSA itself and comorbid obesity, depending on the type of cytokine. Although we did not find apparent interrelationships between systemic and local compartments, further studies are needed to clarify this concept.
PURPOSE: The presence of both systemic and airway inflammation has been suggested in obstructive sleep apnea (OSA) by increased levels of inflammatory biomarkers in the circulation and respiratory specimens. We aimed to investigate the relationship between systemic and airway inflammation in OSA. METHODS: This study was conducted by simultaneously measuring various biomarkers both in serum and induced sputum of 43 patients. We compared the relationships of these biomarker levels with polysomnographic data and obesity measurements and also investigated their interrelationships between systemic and local compartments. We also assessed the relation of inflammatory markers with proximal airway resistance measured by impulse oscillometry. RESULTS: In multiple regression analyses, each measured serum biomarker [leptin, interleukin-6 (IL-6), IL-8, tumor necrosis factor-α (TNF-α), and vascular endothelial growth factor (VEGF)] significantly correlated with waist circumference or fat area determined by computed tomography. In contrast, regarding airway inflammation, sputum IL-6, IL-8, TNF-α, and VEGF significantly correlated with OSA severity as indicated by the respiratory disturbance index or oxygen desaturation indices. Sputum IL-6, IL-8, TNF-α, and VEGF were significantly related to sputum neutrophil number, and sputum IL-8 and TNF-α were related to proximal airway resistance independently of body mass index. There were no significant interrelationships between the same biomarkers in serum and induced sputum. CONCLUSIONS: Systemic and airway inflammation in OSA might be differently regulated by OSA itself and comorbid obesity, depending on the type of cytokine. Although we did not find apparent interrelationships between systemic and local compartments, further studies are needed to clarify this concept.
Authors: K Chin; K Shimizu; T Nakamura; N Narai; H Masuzaki; Y Ogawa; M Mishima; T Nakamura; K Nakao; M Ohi Journal: Circulation Date: 1999-08-17 Impact factor: 29.690
Authors: Graziela De Luca Canto; Camila Pachêco-Pereira; Secil Aydinoz; Paul W Major; Carlos Flores-Mir; David Gozal Journal: Sleep Med Rev Date: 2014-11-28 Impact factor: 11.609
Authors: Habib Mohammad Reazaul Karim; Antonio M Esquinas; Sally Ziatabar; Giuseppe Insalaco; Szymon Skoczyński; Irena Šarc; Luigi Ferini-Strambi; Leyla Pur Özyiğit; Thierry Hernández-Gilsoul; Subrata Kumar Singha; Laura Ciobanu; José Luis Sandoval Gutiérrez; Zbigniew Szkulmowski; Edoardo Piervincenzi; Margarida Aguiar; Mohamad F El-Khatib; Nadia Corcione; Aslıhan Gürün Kaya; Aydın Çiledağ; Akın Kaya; Gabriele Valli; Paola Pierucci; Onofrio Resta; Paschalis Steiropoulos; Francesca De Marco; Vania Caldeira; Bushra A Mina Journal: Turk Thorac J Date: 2020-07
Authors: Andrew M Kim; Brendan T Keenan; Nicholas Jackson; Eugenia L Chan; Bethany Staley; Drew A Torigian; Abass Alavi; Richard J Schwab Journal: Am J Respir Crit Care Med Date: 2014-06-01 Impact factor: 21.405
Authors: C Philippe; Y Boussadia; V Prulière-Escabasse; J F Papon; C Clérici; D Isabey; A Coste; E Escudier; M P d'Ortho Journal: Sleep Breath Date: 2014-07-04 Impact factor: 2.816