INTRODUCTION: From an epidemiological point of view, non-syndromic orofacial clefts are the most common oral congenital deformities worldwide. OBJECTIVE: Family histories were traced and socioeconomic risk factors were identified for non-syndromic cleft lip with or without cleft palate. MATERIAL AND METHODS: A case-control study was carried out with 208 cases of non-syndromic cleft lip with or without cleft palate, and matched by age and sex with 416 controls. Cases were patients attending a referral clinic from 2002 through 2004 in Campeche, Mexico. A questionnaire was administered to collect sociodemographic and socioeconomic variables as well as familial background relevant to non-syndromic cleft lip with or without cleft palate. Conditional logistic regression models were used; adjusted odds ratios and 95% confidence intervals were calculated. RESULTS: In the multivariate model, the following risk factors were identified: 1) low socioeconomic status; 2) birth in the southern region of Campeche state; 3) home delivery or delivery in a publicly funded hospital; 4) occurrence of prior non-syndromic cleft lip with or without cleft palate cases in the father's or mother's family: 5) having a sibling with non-syndromic cleft lip with or without cleft palate; 6) the proband having another malformation, and 7) a history of infections during pregnancy. Prenatal care consisting of vitamin supplementation was a protective factor for non-syndromic cleft lip with or without cleft palate (odds ratio=0.29). CONCLUSIONS: A "social gradient in health" was seen to link oral malformation with diet components, and several socioeconomic and socio-demographic factors broadly encompassed in low socioeconomic status. Further characterization of risk factors will guide the assemblage of a pro-active counseling and prevention program for families at risk for non-syndromic cleft lip and cleft palate.
INTRODUCTION: From an epidemiological point of view, non-syndromic orofacial clefts are the most common oral congenital deformities worldwide. OBJECTIVE: Family histories were traced and socioeconomic risk factors were identified for non-syndromic cleft lip with or without cleft palate. MATERIAL AND METHODS: A case-control study was carried out with 208 cases of non-syndromic cleft lip with or without cleft palate, and matched by age and sex with 416 controls. Cases were patients attending a referral clinic from 2002 through 2004 in Campeche, Mexico. A questionnaire was administered to collect sociodemographic and socioeconomic variables as well as familial background relevant to non-syndromic cleft lip with or without cleft palate. Conditional logistic regression models were used; adjusted odds ratios and 95% confidence intervals were calculated. RESULTS: In the multivariate model, the following risk factors were identified: 1) low socioeconomic status; 2) birth in the southern region of Campeche state; 3) home delivery or delivery in a publicly funded hospital; 4) occurrence of prior non-syndromic cleft lip with or without cleft palate cases in the father's or mother's family: 5) having a sibling with non-syndromic cleft lip with or without cleft palate; 6) the proband having another malformation, and 7) a history of infections during pregnancy. Prenatal care consisting of vitamin supplementation was a protective factor for non-syndromic cleft lip with or without cleft palate (odds ratio=0.29). CONCLUSIONS: A "social gradient in health" was seen to link oral malformation with diet components, and several socioeconomic and socio-demographic factors broadly encompassed in low socioeconomic status. Further characterization of risk factors will guide the assemblage of a pro-active counseling and prevention program for families at risk for non-syndromic cleft lip and cleft palate.
Authors: América P Pontigo-Loyola; Carlo E Medina-Solís; Edith Lara-Carrillo; Nuria Patiño-Marín; Mauricio Escoffié-Ramirez; Martha Mendoza-Rodríguez; Rubén De La Rosa-Santillana; Gerardo Maupomé Journal: Odontology Date: 2012-12-08 Impact factor: 2.634
Authors: Mohammed Junaid; M B Aswath Narayanan; D Jayanthi; S G Ramesh Kumar; A Leena Selvamary Journal: Clin Oral Investig Date: 2017-03-16 Impact factor: 3.573
Authors: Jane C Figueiredo; Stephanie Ly; Kathleen S Magee; Ugonna Ihenacho; James W Baurley; Pedro A Sanchez-Lara; Frederick Brindopke; Thi-Hai-Duc Nguyen; Viet Nguyen; Maria Irene Tangco; Melissa Giron; Tamlin Abrahams; Grace Jang; Annie Vu; Emily Zolfaghari; Caroline A Yao; Athena Foong; Yves A DeClerk; Jonathan M Samet; William Magee Journal: Birth Defects Res A Clin Mol Teratol Date: 2015-08-25
Authors: Miriam del Socorro Herrera; Carlo Eduardo Medina-Solís; Mirna Minaya-Sánchez; América Patricia Pontigo-Loyola; Juan José Villalobos-Rodelo; Horacio Islas-Granillo; Rubén de la Rosa-Santillana; Gerardo Maupomé Journal: Med Sci Monit Date: 2013-11-19