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Literature DB >> 22673981

Drugs targeting mGluR5 receptor offer 'fragile' hope for autism.

Sarah C P Williams.

Abstract

Entities: Disease Gene

Mesh：

Substances：

Year: 2012 PMID： 22673981 DOI： 10.1038/nm0612-840

Source DB: PubMed Journal: Nat Med ISSN： 1078-8956 Impact factor: 53.440

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5 in total

1. New mouse models of autism highlight need for standardized tests.

Authors: Sarah C P Williams
Journal: Nat Med Date: 2011-11-02 Impact factor: 53.440

2. Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autism.

Authors: Jill L Silverman; Daniel G Smith; Stacey J Sukoff Rizzo; Michael N Karras; Sarah M Turner; Seda S Tolu; Dianne K Bryce; Deborah L Smith; Kari Fonseca; Robert H Ring; Jacqueline N Crawley
Journal: Sci Transl Med Date: 2012-04-25 Impact factor: 17.956

3. De novo gene disruptions in children on the autistic spectrum.

Authors: Ivan Iossifov; Michael Ronemus; Dan Levy; Zihua Wang; Inessa Hakker; Julie Rosenbaum; Boris Yamrom; Yoon-Ha Lee; Giuseppe Narzisi; Anthony Leotta; Jude Kendall; Ewa Grabowska; Beicong Ma; Steven Marks; Linda Rodgers; Asya Stepansky; Jennifer Troge; Peter Andrews; Mitchell Bekritsky; Kith Pradhan; Elena Ghiban; Melissa Kramer; Jennifer Parla; Ryan Demeter; Lucinda L Fulton; Robert S Fulton; Vincent J Magrini; Kenny Ye; Jennifer C Darnell; Robert B Darnell; Elaine R Mardis; Richard K Wilson; Michael C Schatz; W Richard McCombie; Michael Wigler
Journal: Neuron Date: 2012-04-26 Impact factor: 17.173

4. Chronic pharmacological mGlu5 inhibition corrects fragile X in adult mice.

Authors: Aubin Michalon; Michael Sidorov; Theresa M Ballard; Laurence Ozmen; Will Spooren; Joseph G Wettstein; Georg Jaeschke; Mark F Bear; Lothar Lindemann
Journal: Neuron Date: 2012-04-12 Impact factor: 17.173

5. High-throughput sequencing of mGluR signaling pathway genes reveals enrichment of rare variants in autism.

Authors: Raymond J Kelleher; Ute Geigenmüller; Hayk Hovhannisyan; Edwin Trautman; Robert Pinard; Barbara Rathmell; Randall Carpenter; David Margulies
Journal: PLoS One Date: 2012-04-27 Impact factor: 3.240

5 in total

4 in total

Drugs targeting mGluR5 receptor offer 'fragile' hope for autism.

1. New mouse models of autism highlight need for standardized tests.

2. Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autism.

3. De novo gene disruptions in children on the autistic spectrum.

4. Chronic pharmacological mGlu5 inhibition corrects fragile X in adult mice.

5. High-throughput sequencing of mGluR signaling pathway genes reveals enrichment of rare variants in autism.

Review 1. Etiology of autism spectrum disorder: a genomics perspective.

2. Aberrant Oscillatory Synchrony Is Biased Toward Specific Frequencies and Processing Domains in the Autistic Brain.

Review 3. Neuron-specific regulation of class I PI3K catalytic subunits and their dysfunction in brain disorders.

4. Cell-specific synaptic plasticity induced by network oscillations.