Literature DB >> 22673256

Venous thromboembolism in the elderly: the result of comorbid conditions or a consequence of injury?

Dennis Y Kim1, Leslie Kobayashi, Galinos Barmparas, Dale Fortlage, Terry Curry, Raul Coimbra.   

Abstract

BACKGROUND: Venous thromboembolism (VTE) is a common complication in trauma patients. Several risk factors have been identified that may place patients at in increased risk for VTE including preexisting medical conditions, iatrogenic factors, and injury-related factors. Advanced age has also been implicated as a risk factor for VTE. The purpose of this study was to determine the incidence and outcomes of VTE in geriatric trauma patients as well as to identify risk factors for VTE in this population.
METHODS: We performed a 10-year retrospective review of all trauma patients aged 65 years or older discharged with a diagnosis of VTE. Demographic data, injuries, mechanism, Injury Severity Score, Abbreviated Injury Score, Glasgow Coma Scale, length of stay, and mortality were collected.
RESULTS: : Of 2,521 trauma patients aged 65 years or older, 82 (3.2%) were diagnosed with VTE. Seventy-two of 82 patients were diagnosed with deep vein thrombosis, and pulmonary embolism was found in 8 patients. Two patients had both a deep vein thrombosis and pulmonary embolism. Independent predictors of VTE included traumatic brain injury (p < 0.05); chest Abbreviated Injury Score ≥ 3 (p < 0.001); mechanical ventilation (p < 0.001); major operation (p < 0.001); and history of VTE (p = 0.05). Other comorbid conditions were not significantly associated with VTE. Preinjury anticoagulation had a trend toward a protective effect. Although length of stay was longer in patients with VTE (adjusted mean difference 14.7 days, p < 0.001), mortality for patients with and without VTE was 8.5% and 7.0%, respectively (p = 0.59).
CONCLUSION: VTE is associated with prolonged length of stay and duration of mechanical ventilation as well as continued medical dependence after discharge. Several risk factors place the elderly trauma patient at an increased risk for VTE, and trauma or injury-related risk factors seem to have a greater impact on the development of VTE in comparison to underlying conditions or increasing patient age (>65 years). LEVEL OF EVIDENCE: II, prognostic study.

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Year:  2012        PMID: 22673256     DOI: 10.1097/TA.0b013e31824ef9ec

Source DB:  PubMed          Journal:  J Trauma Acute Care Surg        ISSN: 2163-0755            Impact factor:   3.313


  4 in total

1.  Dose adjusting enoxaparin is necessary to achieve adequate venous thromboembolism prophylaxis in trauma patients.

Authors:  Todd W Costantini; Emily Min; Kevin Box; Vy Tran; Robert D Winfield; Dale Fortlage; Jay Doucet; Vishal Bansal; Raul Coimbra
Journal:  J Trauma Acute Care Surg       Date:  2013-01       Impact factor: 3.313

Review 2.  Management of Mild Brain Trauma in the Elderly: Literature Review.

Authors:  Federica Marrone; Luca Zavatto; Mario Allevi; Hambra Di Vitantonio; Daniele Francesco Millimaggi; Soheila Raysi Dehcordi; Alessandro Ricci; Graziano Taddei
Journal:  Asian J Neurosurg       Date:  2020-12-21

3.  Venous thromboembolism prophylaxis practice and its association with outcomes in Australia and New Zealand burns patients.

Authors:  Lincoln M Tracy; Peter A Cameron; Yvonne Singer; Arul Earnest; Fiona Wood; Heather Cleland; Belinda J Gabbe
Journal:  Burns Trauma       Date:  2021-02-11

4.  Association of Tranexamic Acid Administration With Mortality and Thromboembolic Events in Patients With Traumatic Injury: A Systematic Review and Meta-analysis.

Authors:  Vivien Karl; Sophie Thorn; Tim Mathes; Simone Hess; Marc Maegele
Journal:  JAMA Netw Open       Date:  2022-03-01
  4 in total

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