BACKGROUND:Noninvasive ventilation (NIV), a technique widely used in intensive care units (ICUs), eliminates the need for many patients in respiratory failure to undergo intubation. However, few articles have described how to wean patients from NIV. Herein, we put forward a protocol to be performed by respiratory therapists to wean patients from NIV. METHODS: A prospective, randomized, controlled trial was performed in a respiratory ICU of a teaching hospital. Respiratory therapists screened patients daily. In the protocol-directed weaning group, the weaning attempt was initiated according to the protocol. In the physician-directed weaning group, the weaning attempt was initiated according to physicians' orders. RESULTS: At randomization, patients in the two groups had similar clinical characteristics. A total of 73 patients were successfully weaned from NIV (37 in the protocol-directed group and 36 in the physician-directed group). The preponderance of them (64%) was chronic obstructive pulmonary disease patients. Compared with physician-directed weaning, protocol-directed weaning reduced the duration of NIV (4.4 ± 2.5 days vs. 2.6 ± 1.5 days, respectively, p < 0.001) and the duration of the ICU stay (8.1 ± 5.5 days vs. 5.8 ± 2.7 days, respectively, p = 0.02). In the protocol-directed group, the successful weaning rate was 57%, 27%, 13%, 0%, and 3% on the 1st, 2nd, 3rd, 4th, and 5th days after randomization, respectively. CONCLUSIONS: Protocol-directed weaning reduces the duration of NIV and the duration of the ICU stay. LEVEL OF EVIDENCE: II.
RCT Entities:
BACKGROUND: Noninvasive ventilation (NIV), a technique widely used in intensive care units (ICUs), eliminates the need for many patients in respiratory failure to undergo intubation. However, few articles have described how to wean patients from NIV. Herein, we put forward a protocol to be performed by respiratory therapists to wean patients from NIV. METHODS: A prospective, randomized, controlled trial was performed in a respiratory ICU of a teaching hospital. Respiratory therapists screened patients daily. In the protocol-directed weaning group, the weaning attempt was initiated according to the protocol. In the physician-directed weaning group, the weaning attempt was initiated according to physicians' orders. RESULTS: At randomization, patients in the two groups had similar clinical characteristics. A total of 73 patients were successfully weaned from NIV (37 in the protocol-directed group and 36 in the physician-directed group). The preponderance of them (64%) was chronic obstructive pulmonary diseasepatients. Compared with physician-directed weaning, protocol-directed weaning reduced the duration of NIV (4.4 ± 2.5 days vs. 2.6 ± 1.5 days, respectively, p < 0.001) and the duration of the ICU stay (8.1 ± 5.5 days vs. 5.8 ± 2.7 days, respectively, p = 0.02). In the protocol-directed group, the successful weaning rate was 57%, 27%, 13%, 0%, and 3% on the 1st, 2nd, 3rd, 4th, and 5th days after randomization, respectively. CONCLUSIONS: Protocol-directed weaning reduces the duration of NIV and the duration of the ICU stay. LEVEL OF EVIDENCE: II.
Authors: Kimberly A Fisher; Kathleen M Mazor; Sarah Goff; Mihaela S Stefan; Penelope S Pekow; Lauren A Williams; Vida Rastegar; Michael B Rothberg; Nicholas S Hill; Peter K Lindenauer Journal: Ann Am Thorac Soc Date: 2017-11
Authors: Josep Masip; W Frank Peacock; Susanna Price; Louise Cullen; F Javier Martin-Sanchez; Petar Seferovic; Alan S Maisel; Oscar Miro; Gerasimos Filippatos; Christiaan Vrints; Michael Christ; Martin Cowie; Elke Platz; John McMurray; Salvatore DiSomma; Uwe Zeymer; Hector Bueno; Chris P Gale; Maddalena Lettino; Mucio Tavares; Frank Ruschitzka; Alexandre Mebazaa; Veli-Pekka Harjola; Christian Mueller Journal: Eur Heart J Date: 2018-01-01 Impact factor: 29.983
Authors: Paola Faverio; Anna Stainer; Federica De Giacomi; Grazia Messinesi; Valentina Paolini; Anna Monzani; Paolo Sioli; Irdi Memaj; Oriol Sibila; Paolo Mazzola; Alberto Pesci Journal: Can Respir J Date: 2019-03-25 Impact factor: 2.409