Y Teuschl1, K Matz, M Brainin. 1. Department for Clinical Neurosciences and Preventive Medicine, Danube University Krems, Krems, Austria.
Abstract
BACKGROUND AND PURPOSE: Despite a high prevalence of post-stroke cognitive impairment, therapeutic possibilities are still limited. Stroke and dementia share the same cluster of modifiable risk factors. Thus, lifestyle interventions and strict adherence to medication may not only decrease the risk of recurrent stroke but also the risk of post-stroke cognitive decline. METHODS: We performed a systematic literature search for randomized clinical trials (RCTs) targeting modifiable risk factors for the prevention of cognitive decline following stroke. RESULTS: We identified 25 non-pharmacological interventions and eight multiple risk factor interventions in stroke patients using cognition as outcome measure. None of the published trials investigated interventions aimed at the prevention of post-stroke cognitive decline. However, a number of ongoing trials aim at risk factor reduction and include measures on cognition. CONCLUSION: Evidence for risk factor modification for the prevention of cognitive decline after stroke is scarce and comes mainly from observational studies. There is a need for more RCTs targeting the prevention of post-stroke dementia using lifestyle interventions and a multiple risk factor approach.
BACKGROUND AND PURPOSE: Despite a high prevalence of post-stroke cognitive impairment, therapeutic possibilities are still limited. Stroke and dementia share the same cluster of modifiable risk factors. Thus, lifestyle interventions and strict adherence to medication may not only decrease the risk of recurrent stroke but also the risk of post-stroke cognitive decline. METHODS: We performed a systematic literature search for randomized clinical trials (RCTs) targeting modifiable risk factors for the prevention of cognitive decline following stroke. RESULTS: We identified 25 non-pharmacological interventions and eight multiple risk factor interventions in strokepatients using cognition as outcome measure. None of the published trials investigated interventions aimed at the prevention of post-stroke cognitive decline. However, a number of ongoing trials aim at risk factor reduction and include measures on cognition. CONCLUSION: Evidence for risk factor modification for the prevention of cognitive decline after stroke is scarce and comes mainly from observational studies. There is a need for more RCTs targeting the prevention of post-stroke dementia using lifestyle interventions and a multiple risk factor approach.
Authors: Régis Bordet; Ralf Ihl; Amos D Korczyn; Giuseppe Lanza; Jelka Jansa; Robert Hoerr; Alla Guekht Journal: BMC Med Date: 2017-05-24 Impact factor: 8.775
Authors: Y Teuschl; H Ihle-Hansen; K Matz; A Dachenhausen; P Ratajczak; J Tuomilehto; M H Ursin; G Hagberg; B Thommessen; A R Øksengård; M Brainin Journal: Eur J Neurol Date: 2018-06-22 Impact factor: 6.089
Authors: Alla Guekht; Ingmar Skoog; Amos D Korczyn; Vladimir Zakharov; Martin Eeg; Ulf Vigonius Journal: Dement Geriatr Cogn Dis Extra Date: 2013-12-14