Literature DB >> 22671021

A prospective study to assess the palatability of analgesic medicines in children.

Coral June Smith1, Helen M Sammons, Apostolos Fakis, Sharon Conroy.   

Abstract

AIM: This study examined children's opinions on the taste of three analgesic medicines: paracetamol, ibuprofen and codeine.
BACKGROUND: Many medicines for children are unpleasant and unacceptable. Research has shown that children's taste preferences differ to adults, in whom palatability is often tested. Little British research exists on children's opinions on the palatability of medicines. This study aimed to address this gap in knowledge.
DESIGN: Prospective observational study.
METHODS: Between May-September 2008, hospital inpatients aged 5-16 years rated the taste of required analgesics on a 100-mm visual analogue scale. This incorporated a 5-point facial hedonic scale. They were also asked their favourite flavour and colour for a medicine.
RESULTS: A total of 159 children took part. Eighty-five males (53·5%) and 74 females (46·5%). The median age was 8 years (Inter-quartile range 6-11). The taste of ibuprofen was significantly preferred to paracetamol or codeine. Significant differences were observed depending if the medicine rated was taken first or second (for example pre-medication with paracetamol and ibuprofen). Younger children (5-8 years) were more likely to choose the extremes of the scale when grading than older children were. Preferred flavours on questioning were strawberry 44% and banana 17%. Favourite colours were pink 25·8% and red 20·8%, with girls more likely to choose pink and boys blue.
CONCLUSION: Ibuprofen was the most palatable analgesic medicine tested. Children reported they preferred fruit flavours and colour was sex dependent. Nurses when administering two medicines together should consider giving the least palatable first, for example paracetamol before ibuprofen for pre-medication.
© 2012 Blackwell Publishing Ltd.

Entities:  

Mesh:

Substances:

Year:  2012        PMID: 22671021     DOI: 10.1111/j.1365-2648.2012.06050.x

Source DB:  PubMed          Journal:  J Adv Nurs        ISSN: 0309-2402            Impact factor:   3.187


  11 in total

Review 1.  Orally disintegrating films and mini-tablets-innovative dosage forms of choice for pediatric use.

Authors:  Maren Preis
Journal:  AAPS PharmSciTech       Date:  2015-03-05       Impact factor: 3.246

Review 2.  Methodology Used to Assess Acceptability of Oral Pediatric Medicines: A Systematic Literature Search and Narrative Review.

Authors:  Punam Mistry; Hannah Batchelor
Journal:  Paediatr Drugs       Date:  2017-06       Impact factor: 3.022

3.  Enduring large use of acetaminophen suppositories for fever management in children: a national survey of French parents and healthcare professionals' practices.

Authors:  Nathalie Bertille; Elisabeth Fournier-Charrière; Gérard Pons; Babak Khoshnood; Martin Chalumeau
Journal:  Eur J Pediatr       Date:  2016-05-19       Impact factor: 3.183

Review 4.  Patient-centred pharmaceutical design to improve acceptability of medicines: similarities and differences in paediatric and geriatric populations.

Authors:  Fang Liu; Sejal Ranmal; Hannah K Batchelor; Mine Orlu-Gul; Terry B Ernest; Iwan W Thomas; Talia Flanagan; Catherine Tuleu
Journal:  Drugs       Date:  2014-10       Impact factor: 9.546

5.  Observational study on the palatability and tolerability of oral prednisolone and oral dexamethasone in children in Saudi Arabia and the UK.

Authors:  Fahad Aljebab; Mofadhi Alanazi; Imti Choonara; Sharon Conroy
Journal:  Arch Dis Child       Date:  2017-07-22       Impact factor: 3.791

6.  Acceptability of a first-line anti-tuberculosis formulation for children: qualitative data from the SHINE trial.

Authors:  D T Wademan; L Busakwe; T J Nicholson; M van der Zalm; M Palmer; J Workman; A Turkova; A M Crook; M J Thomason; D M Gibb; J Seeley; A Hesseling; G Hoddinott
Journal:  Int J Tuberc Lung Dis       Date:  2019-12-01       Impact factor: 2.373

7.  The stuff that dreams are made of: HIV-positive adolescents' aspirations for development.

Authors:  Rebecca Hodes; Jenny Doubt; Elona Toska; Beth Vale; Nompumelelo Zungu; Lucie Cluver
Journal:  J Int AIDS Soc       Date:  2018-02       Impact factor: 5.396

8.  Evaluation of patient-reported outcome measurements as a reliable tool to measure acceptability of the taste of paediatric medicines in an inpatient paediatric population.

Authors:  Punam Mistry; Heather Stirling; Claire Callens; James Hodson; Hannah Batchelor
Journal:  BMJ Open       Date:  2018-07-11       Impact factor: 2.692

9.  Toward Improving Medication Adherence: The Suppression of Bitter Taste in Edible Taste Films.

Authors:  Silvy Cherian; Brian Sang Lee; Robin M Tucker; Kevin Lee; Gregory Smutzer
Journal:  Adv Pharmacol Sci       Date:  2018-06-25

10.  A pharmacokinetic study of radiprodil oral suspension in healthy adults comparing conventional venous blood sampling with two microsampling techniques.

Authors:  David Sciberras; Christian Otoul; Françoise Lurquin; John Smeraglia; Aurélia Lappert; Steven De Bruyn; Jan Jaap van Lier
Journal:  Pharmacol Res Perspect       Date:  2019-01-28
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.