Literature DB >> 22670838

Novel compounds and drugs and recent patents in treating multidrug-resistant and extensively drug-resistant tuberculosis.

Attapon Cheepsattayakorn1, Ruangrong Cheepsattayakorn.   

Abstract

A number of recent studies revealed that successful treatment of the patients with MDR/XDR- TB was not achieved due to high resistant rates to many second-line drugs such as kanamycin and prothionamide including poor adherence of the lengthy treatment. Many new drugs and compounds such as benzothiazinones, meropenem, PA-824, isoflavonoids, rhein, PNU-100480, TMC207, SQ109, OPC-67683, AZD5847, and linezolid are currently in development pipeline. According to very few patents in new compounds and drugs against MDR/XDRMycobacterium tuberculosis bacilli have been currently introduced, so inventors must be encouraged to contribute to this area worldwide.

Entities:  

Mesh：

Substances：

Year:  2012        PMID： 22670838     DOI： 10.2174/157489112801619683

Source DB:  PubMed          Journal:  Recent Pat Antiinfect Drug Discov        ISSN： 1574-891X


  4 in total

1.  1H-Benzo[d]Imidazole Derivatives Affect MmpL3 in Mycobacterium tuberculosis.

Authors:  Małgorzata Korycka-Machała; Albertus Viljoen; Jakub Pawełczyk; Paulina Borówka; Bożena Dziadek; Katarzyna Gobis; Anna Brzostek; Malwina Kawka; Mickael Blaise; Dominik Strapagiel; Laurent Kremer; Jarosław Dziadek
Journal:  Antimicrob Agents Chemother       Date:  2019-09-23       Impact factor: 5.191

2.  Screening and Development of New Inhibitors of FtsZ from M. Tuberculosis.

Authors:  Bini Mathew; Judith Varady Hobrath; Larry Ross; Michele C Connelly; Hava Lofton; Malini Rajagopalan; R Kiplin Guy; Robert C Reynolds
Journal:  PLoS One       Date:  2016-10-21       Impact factor: 3.240

3.  Evaluation of the Mycobactericidal Effect of Thio-functionalized Carbohydrate Derivatives.

Authors:  Małgorzata Korycka-Machała; Anna Brzostek; Bożena Dziadek; Malwina Kawka; Tomasz Popławski; Zbigniew J Witczak; Jarosław Dziadek
Journal:  Molecules       Date:  2017-05-16       Impact factor: 4.411

4.  Incidence and predictors of mortality among persons receiving second-line tuberculosis treatment in sub-Saharan Africa: A meta-analysis of 43 cohort studies.

Authors:  Dumessa Edessa; Fuad Adem; Bisrat Hagos; Mekonnen Sisay
Journal:  PLoS One       Date:  2021-12-10       Impact factor: 3.240
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.