OBJECTIVES: The objective of this study was to assess the incidence and common types of concomitant malignancies and to define predictive factors of death in Korean patients with idiopathic inflammatory myopathy (IIM). METHODS: From January 1989 to May 2011, 162 patients were diagnosed with IIM at a university hospital in Korea. The medical records were retrospectively reviewed. The clinical findings of the patients were compared for malignancy, and the prognostic factors predicting death were analyzed. RESULTS: Malignancies were found in 17 patients (10.5 %), all of whom had a significantly lower frequency of interstitial lung disease (ILD) and an older age at onset. The main causes of death were ILD and malignancy. Older age at diagnosis, presence of malignancy, rapidly progressive ILD and minimal creatinine phosphokinase (CPK) elevation were independent risk factors for death. CONCLUSIONS: Malignancy was one of the most serious risk factor for death in our patients with IIM. Early discovery of malignancy is important, and an extensive investigation for common malignancies in each region should be done at diagnosis and for a minimum of 2 years thereafter. As minimally elevated CPK levels in ILD patients may be associated with fatal ILD, an early evaluation and a more aggressive treatment of ILD should be considered in these patients.
OBJECTIVES: The objective of this study was to assess the incidence and common types of concomitant malignancies and to define predictive factors of death in Korean patients with idiopathic inflammatory myopathy (IIM). METHODS: From January 1989 to May 2011, 162 patients were diagnosed with IIM at a university hospital in Korea. The medical records were retrospectively reviewed. The clinical findings of the patients were compared for malignancy, and the prognostic factors predicting death were analyzed. RESULTS:Malignancies were found in 17 patients (10.5 %), all of whom had a significantly lower frequency of interstitial lung disease (ILD) and an older age at onset. The main causes of death were ILD and malignancy. Older age at diagnosis, presence of malignancy, rapidly progressive ILD and minimal creatinine phosphokinase (CPK) elevation were independent risk factors for death. CONCLUSIONS:Malignancy was one of the most serious risk factor for death in our patients with IIM. Early discovery of malignancy is important, and an extensive investigation for common malignancies in each region should be done at diagnosis and for a minimum of 2 years thereafter. As minimally elevated CPK levels in ILDpatients may be associated with fatal ILD, an early evaluation and a more aggressive treatment of ILD should be considered in these patients.
Authors: Rebeccah M Brusca; Iago Pinal-Fernandez; Kevin Psoter; Julie J Paik; Jemima Albayda; Christopher Mecoli; Eleni Tiniakou; Andrew L Mammen; Lisa Christopher-Stine; Sonye Danoff; Cheilonda Johnson Journal: Respir Med Date: 2019-02-21 Impact factor: 3.415
Authors: Adam M Huber; Gulnara Mamyrova; Peter A Lachenbruch; Julia A Lee; James D Katz; Ira N Targoff; Frederick W Miller; Lisa G Rider Journal: Arthritis Care Res (Hoboken) Date: 2014-05 Impact factor: 4.794
Authors: Ghassan Aljohani; Eman A Bin Awad; Khalid Alshahrani; Mubark M Alsaqar; Bashayer Albogami; Saleh H Almotywee; Hisham Almaimouni; Abdullah S Dirar; Abdulrahman Alrashid; Rajkumar Rajendram; Emad Masuadi; Mohammed A Omair Journal: Saudi Med J Date: 2021-01 Impact factor: 1.484