PURPOSE: Natural killer (NK) cells express killer immunoglobulin-like receptors (KIRs) which recognize HLA class I molecules on trophoblasts. KIRs could either activate NK cells or inhibit them to produce soluble factors necessary for the maintenance of pregnancy, thus they are suspected of being involved in the causes of recurrent miscarriage. The aim of this study was to evaluate whether there is any possible association between KIR genes, genotypes and recurrent miscarriage. METHODS: The present study was carried out on 40 women who had unexplained recurrent miscarriage and 90 controls. Sequence-specific oligonucleotide probes analysis were used to investigate 16 KIR genes. All data were statistically analyzed by Fisher Exact Test. RESULTS: The rate of Bx genotypes that consists elevated number of activating KIR genes was significantly higher (p = 0.014) in women with recurrent miscarriage when compared with the control group. Additionally, the frequency of AA genotype (AA1) of the subjects in the study group was significantly lower than the frequency of the subjects in the control group (p = 0,014). Furthermore, there were no statistically significant differences in the frequencies of the individual KIR genes between women with recurrent miscarriage and the control group. CONCLUSIONS: Inclined balance of KIRs toward an activating state in NK cells may contribute to recurrent miscarriage.
PURPOSE: Natural killer (NK) cells express killer immunoglobulin-like receptors (KIRs) which recognize HLA class I molecules on trophoblasts. KIRs could either activate NK cells or inhibit them to produce soluble factors necessary for the maintenance of pregnancy, thus they are suspected of being involved in the causes of recurrent miscarriage. The aim of this study was to evaluate whether there is any possible association between KIR genes, genotypes and recurrent miscarriage. METHODS: The present study was carried out on 40 women who had unexplained recurrent miscarriage and 90 controls. Sequence-specific oligonucleotide probes analysis were used to investigate 16 KIR genes. All data were statistically analyzed by Fisher Exact Test. RESULTS: The rate of Bx genotypes that consists elevated number of activating KIR genes was significantly higher (p = 0.014) in women with recurrent miscarriage when compared with the control group. Additionally, the frequency of AA genotype (AA1) of the subjects in the study group was significantly lower than the frequency of the subjects in the control group (p = 0,014). Furthermore, there were no statistically significant differences in the frequencies of the individual KIR genes between women with recurrent miscarriage and the control group. CONCLUSIONS: Inclined balance of KIRs toward an activating state in NK cells may contribute to recurrent miscarriage.
Authors: Izabela Nowak; Andrzej Malinowski; Henryk Tchórzewski; Ewa Barcz; Jacek R Wilczyński; Małgorzata Banasik; Marian Gryboś; Maciej Kurpisz; Wioleta Luszczek; Edyta Majorczyk; Andrzej Wiśniewski; David Senitzer; Ji Yao Sun; Piotr Kuśnierczyk Journal: J Reprod Immunol Date: 2010-12-04 Impact factor: 4.054
Authors: Silvia Giugliano; Margaret G Petroff; Bryce D Warren; Susmita Jasti; Caitlin Linscheid; Ashley Ward; Anita Kramer; Evgenia Dobrinskikh; Melissa A Sheiko; Michael Gale; Lucy Golden-Mason; Virginia D Winn; Hugo R Rosen Journal: J Immunol Date: 2015-09-04 Impact factor: 5.422
Authors: Isabel Legaz; Jose Miguel Bolarín; Elena Navarro; Jose Antonio Campillo; Rosa Moya; María Dolores Pérez-Cárceles; Aurelio Luna; Eduardo Osuna; Manuel Miras; Manuel Muro; Alfredo Minguela; Rocio Alvarez López Journal: Arch Med Sci Date: 2019-04-09 Impact factor: 3.318