Yingxin Yang1, Zhen Li, Ningli Wang, Lie Wu, Yi Zhen, Tao Wang, Caixia Ren, Xiaoxia Peng, Jie Hao, Yanting Xia. 1. *Guang'anmen Hospital, China Academy of Chinese Medical Sciences †Beijing Tongren Eye Center, Beijing Tongren Hospital ∥Department of Epidemiology and Biostatistics, School of Public Health and Family Medicine ‡Department of Ophthalmology, Xuan Wu Hospital, Capital Medical University, Beijing §Department of Anatomy, Histology and Embryology, Peking University School of Basic Medical Sciences ¶Beijing University of Chinese Medicine, Beijing, PR China.
Abstract
PURPOSE: To investigate whether patients with primary open-angle glaucoma combined with high myopia (POAG-HM) have short-term intraocular pressure (IOP) fluctuations at resting conditions over 24 hours and after dynamic exercise. METHODS: Prospective Control Clinical Study. Eighty eyes of 80 high-tension Chinese POAG patients only on prostaglandin analog locally were categorized as per their degree of myopia (myopes 6 D or more, n=30 and between -0.76 and -5.99 D, n=29) or without myopia (n=21). Twenty-four-hour IOP fluctuations at resting conditions were observed in protocol 1, and IOP fluctuations after 10-minute exercise at 20% maximum Watt (Wmax) and followed by 5 minutes of exercise at 60% Wmax were observed in protocol 2. RESULTS: Twenty-four-hour IOP fluctuations at resting conditions were not statistically significant among groups (P=0.58). After 10 minutes of moderate (20% Wmax) exercise, patients with POAG-HM had significant IOP decrease (3.50±2.76 mm Hg) over other subjects (analysis of covariance, age, as a covariate, was controlled, P=0.02). After 5 minutes of heavy (60% Wmax) exercise, patients with POAG-HM had significantly a greater postexercise IOP decrease (7.57±3.47 mm Hg) than other groups (P=0.00). CONCLUSIONS: High-tension POAG patients with high myopia on only pharmacological glaucoma therapy have significantly greater IOP fluctuations after moderate and heavy exercise and do not have greater 24-hour IOP fluctuations at resting conditions.
PURPOSE: To investigate whether patients with primary open-angle glaucoma combined with high myopia (POAG-HM) have short-term intraocular pressure (IOP) fluctuations at resting conditions over 24 hours and after dynamic exercise. METHODS: Prospective Control Clinical Study. Eighty eyes of 80 high-tension Chinese POAG patients only on prostaglandin analog locally were categorized as per their degree of myopia (myopes 6 D or more, n=30 and between -0.76 and -5.99 D, n=29) or without myopia (n=21). Twenty-four-hour IOP fluctuations at resting conditions were observed in protocol 1, and IOP fluctuations after 10-minute exercise at 20% maximum Watt (Wmax) and followed by 5 minutes of exercise at 60% Wmax were observed in protocol 2. RESULTS: Twenty-four-hour IOP fluctuations at resting conditions were not statistically significant among groups (P=0.58). After 10 minutes of moderate (20% Wmax) exercise, patients with POAG-HM had significant IOP decrease (3.50±2.76 mm Hg) over other subjects (analysis of covariance, age, as a covariate, was controlled, P=0.02). After 5 minutes of heavy (60% Wmax) exercise, patients with POAG-HM had significantly a greater postexercise IOP decrease (7.57±3.47 mm Hg) than other groups (P=0.00). CONCLUSIONS: High-tension POAG patients with high myopia on only pharmacological glaucoma therapy have significantly greater IOP fluctuations after moderate and heavy exercise and do not have greater 24-hour IOP fluctuations at resting conditions.