Literature DB >> 22668859

Characterization of a novel IMP-28 metallo-β-lactamase from a Spanish Klebsiella oxytoca clinical isolate.

Francisco José Pérez-Llarena1, Ana Fernández, Laura Zamorano, Frédéric Kerff, Alejandro Beceiro, Belén Aracil, Emilia Cercenado, Elisenda Miro, Antonio Oliver, Jesús Oteo, Ferran Navarro, Germán Bou.   

Abstract

An isolate of Klebsiella oxytoca carrying a novel IMP metallo-β-lactamase was discovered in Madrid, Spain. The bla(IMP-28) gene is part of a chromosomally located class I integron. The IMP-28 k(cat)/K(m) values for ampicillin, ceftazidime, and cefepime and, to a lesser extent, imipenem and meropenem, are clearly lower than those of IMP-1. The His306Gln mutation may induce important modifications of the L3 loop and thus of substrate accessibility and hydrolysis and be the main reason for this behavior.

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Year:  2012        PMID： 22668859      PMCID： PMC3421603          DOI： 10.1128/AAC.00776-12

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  18 in total

1.  Plasmid-encoded metallo-beta-lactamase (IMP-6) conferring resistance to carbapenems, especially meropenem.

Authors:  H Yano; A Kuga; R Okamoto; H Kitasato; T Kobayashi; M Inoue
Journal:  Antimicrob Agents Chemother       Date:  2001-05       Impact factor: 5.191

Review 2.  New beta-lactamases in gram-negative bacteria: diversity and impact on the selection of antimicrobial therapy.

Authors:  K Bush
Journal:  Clin Infect Dis       Date:  2001-03-21       Impact factor: 9.079

3.  Genetic context and biochemical characterization of the IMP-18 metallo-beta-lactamase identified in a Pseudomonas aeruginosa isolate from the United States.

Authors:  Luisa Borgianni; Silvia Prandi; Laurie Salden; Gisela Santella; Nancy D Hanson; Gian Maria Rossolini; Jean-Denis Docquier
Journal:  Antimicrob Agents Chemother       Date:  2010-11-01       Impact factor: 5.191

4.  A tripeptide deletion in the R2 loop of the class C beta-lactamase enzyme FOX-4 impairs cefoxitin hydrolysis and slightly increases susceptibility to beta-lactamase inhibitors.

Authors:  Susana Mallo; Francisco J Pérez-Llarena; Fréderic Kerff; Nelson C Soares; Moreno Galleni; Germán Bou
Journal:  J Antimicrob Chemother       Date:  2010-04-09       Impact factor: 5.790

5.  IMP-12, a new plasmid-encoded metallo-beta-lactamase from a Pseudomonas putida clinical isolate.

Authors:  Jean-Denis Docquier; Maria Letizia Riccio; Claudia Mugnaioli; Francesco Luzzaro; Andrea Endimiani; Antonio Toniolo; Gianfranco Amicosante; Gian Maria Rossolini
Journal:  Antimicrob Agents Chemother       Date:  2003-05       Impact factor: 5.191

6.  Amino acid substitutions in a variant of IMP-1 metallo-beta-lactamase.

Authors:  S Iyobe; H Kusadokoro; J Ozaki; N Matsumura; S Minami; S Haruta; T Sawai; K O'Hara
Journal:  Antimicrob Agents Chemother       Date:  2000-08       Impact factor: 5.191

7.  Biochemical characterization of the Pseudomonas aeruginosa 101/1477 metallo-beta-lactamase IMP-1 produced by Escherichia coli.

Authors:  N Laraki; N Franceschini; G M Rossolini; P Santucci; C Meunier; E de Pauw; G Amicosante; J M Frère; M Galleni
Journal:  Antimicrob Agents Chemother       Date:  1999-04       Impact factor: 5.191

8.  Structure of In31, a blaIMP-containing Pseudomonas aeruginosa integron phyletically related to In5, which carries an unusual array of gene cassettes.

Authors:  N Laraki; M Galleni; I Thamm; M L Riccio; G Amicosante; J M Frère; G M Rossolini
Journal:  Antimicrob Agents Chemother       Date:  1999-04       Impact factor: 5.191

9.  Genomic mapping with I-Ceu I, an intron-encoded endonuclease specific for genes for ribosomal RNA, in Salmonella spp., Escherichia coli, and other bacteria.

Authors:  S L Liu; A Hessel; K E Sanderson
Journal:  Proc Natl Acad Sci U S A       Date:  1993-07-15       Impact factor: 11.205

10.  Relevance of resistance levels to carbapenems and integron-borne blaIMP-1, blaIMP-7, blaIMP-10 and blaVIM-2 in clinical isolates of Pseudomonas aeruginosa.

Authors:  Wei-Hua Zhao; Gelin Chen; Ribu Ito; Zhi-Qing Hu
Journal:  J Med Microbiol       Date:  2009-06-15       Impact factor: 2.472
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  8 in total

1.  Mobile genetic elements related to the diffusion of plasmid-mediated AmpC β-lactamases or carbapenemases from Enterobacteriaceae: findings from a multicenter study in Spain.

Authors:  L Zamorano; E Miró; C Juan; L Gómez; G Bou; J J González-López; L Martínez-Martínez; B Aracil; M C Conejo; A Oliver; F Navarro
Journal:  Antimicrob Agents Chemother       Date:  2015-06-15       Impact factor: 5.191

2.  Prevalence and molecular epidemiology of acquired AmpC β-lactamases and carbapenemases in Enterobacteriaceae isolates from 35 hospitals in Spain.

Authors:  E Miró; J Agüero; M N Larrosa; A Fernández; M C Conejo; G Bou; J J González-López; N Lara; L Martínez-Martínez; A Oliver; B Aracil; J Oteo; A Pascual; J Rodríguez-Baño; L Zamorano; F Navarro
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2012-09-07       Impact factor: 3.267

Review 3.  Antimicrobial resistance and virulence: a successful or deleterious association in the bacterial world?

Authors:  Alejandro Beceiro; María Tomás; Germán Bou
Journal:  Clin Microbiol Rev       Date:  2013-04       Impact factor: 26.132

Review 4.  B1-Metallo-β-Lactamases: Where Do We Stand?

Authors:  Maria F Mojica; Robert A Bonomo; Walter Fast
Journal:  Curr Drug Targets       Date:  2016       Impact factor: 3.465

5.  Genetic and kinetic characterization of the novel AmpC β-lactamases DHA-6 and DHA-7.

Authors:  Francisco José Pérez-Llarena; Laura Zamorano; Frédéric Kerff; Alejandro Beceiro; Patricia García; Elisenda Miró; Nieves Larrosa; Frederic Gómez-Bertomeu; José Antonio Méndez; Juan José González-López; Antonio Oliver; Moreno Galleni; Ferran Navarro; Germán Bou
Journal:  Antimicrob Agents Chemother       Date:  2014-08-18       Impact factor: 5.191

6.  Selection of AmpC β-Lactamase Variants and Metallo-β-Lactamases Leading to Ceftolozane/Tazobactam and Ceftazidime/Avibactam Resistance during Treatment of MDR/XDR Pseudomonas aeruginosa Infections.

Authors:  Alba Ruedas-López; Isaac Alonso-García; Cristina Lasarte-Monterrubio; Paula Guijarro-Sánchez; Eva Gato; Juan Carlos Vázquez-Ucha; Juan Andrés Vallejo; Pablo Arturo Fraile-Ribot; Begoña Fernández-Pérez; David Velasco; José María Gutiérrez-Urbón; Marina Oviaño; Alejandro Beceiro; Concepción González-Bello; Antonio Oliver; Jorge Arca-Suárez; Germán Bou
Journal:  Antimicrob Agents Chemother       Date:  2021-12-20       Impact factor: 5.938

7.  Klebsiella oxytoca Complex: Update on Taxonomy, Antimicrobial Resistance, and Virulence.

Authors:  Jing Yang; Haiyan Long; Ya Hu; Yu Feng; Alan McNally; Zhiyong Zong
Journal:  Clin Microbiol Rev       Date:  2021-12-01       Impact factor: 50.129

8.  Phenotypic and molecular characterization of IMP-producing Enterobacterales in Spain: Predominance of IMP-8 in Klebsiella pneumoniae and IMP-22 in Enterobacter roggenkampii.

Authors:  Javier E Cañada-García; Natalin Grippo; Eva Ramírez de Arellano; Verónica Bautista; Noelia Lara; Ana María Navarro; Teresa Cabezas; Nora Mariela Martínez-Ramírez; Silvia García-Cobos; Jorge Calvo; Emilia Cercenado; Belén Aracil; María Pérez-Vázquez; Jesús Oteo-Iglesias
Journal:  Front Microbiol       Date:  2022-09-28       Impact factor: 6.064
  8 in total

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