OBJECTIVE: The aim of this study was to assess the relevance of clinical and histopathologic parameters on survival of oral squamous cell carcinoma (OSCC) patients in Sri Lanka. STUDY DESIGN: A cohort of 193 previously diagnosed OSCC patients were followed for up to 5 years. Clinical and histopathologic parameters were analyzed regarding local recurrence and 5-year survival after treatment. RESULTS: Site, stage, local recurrence, degree of differentiation, degree of keratinization, pattern of invasion, and status of the excision margins showed a significant association with the 5-year survival (P < .05). Multivariate analysis identified stage, pattern of invasion, and status of the excision margins as true independent prognostic indicators of OSCC. Pattern of invasion was the best prognosticator of both local recurrence and overall survival in the Cox regression model (P < .001). CONCLUSIONS: Stage, pattern of invasion, and status of the excision margins are superior prognostic indicators of OSCC compared with other parameters. Copyright Â
OBJECTIVE: The aim of this study was to assess the relevance of clinical and histopathologic parameters on survival of oral squamous cell carcinoma (OSCC) patients in Sri Lanka. STUDY DESIGN: A cohort of 193 previously diagnosed OSCC patients were followed for up to 5 years. Clinical and histopathologic parameters were analyzed regarding local recurrence and 5-year survival after treatment. RESULTS: Site, stage, local recurrence, degree of differentiation, degree of keratinization, pattern of invasion, and status of the excision margins showed a significant association with the 5-year survival (P < .05). Multivariate analysis identified stage, pattern of invasion, and status of the excision margins as true independent prognostic indicators of OSCC. Pattern of invasion was the best prognosticator of both local recurrence and overall survival in the Cox regression model (P < .001). CONCLUSIONS: Stage, pattern of invasion, and status of the excision margins are superior prognostic indicators of OSCC compared with other parameters. Copyright Â
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Authors: Adrian Pătru; Valeriu Şurlin; Claudiu Mărgăritescu; Eduard Mihai Ciucă; Marius Matei; Mircea Sebastian Şerbănescu; Adrian Camen Journal: Rom J Morphol Embryol Date: 2020 Oct-Dec Impact factor: 0.833
Authors: Alhadi Almangush; Ibrahim O Bello; Harri Keski-Säntti; Laura K Mäkinen; Joonas H Kauppila; Matti Pukkila; Jaana Hagström; Jussi Laranne; Satu Tommola; Outi Nieminen; Ylermi Soini; Veli-Matti Kosma; Petri Koivunen; Reidar Grénman; Ilmo Leivo; Tuula Salo Journal: Head Neck Date: 2013-09-02 Impact factor: 3.147