Literature DB >> 22665711

Diabetes in the young but not needing insulin--what type is it?

Umesh Dashora1, Rachael Golton, Amanda Combes, Sathis Kumar.   

Abstract

A 57-year-old female who was diagnosed with diabetes at the age of 22 is presented. She was initially controlled with diet alone and then was prescribed oral glucose lowering treatment over the next 35 years. She was referred to the diabetes clinic for insulin start because of poor control of diabetes. In view of her presentation at such a young age and strong family history, a possibility of maturity onset diabetes in young was considered and the genetic test confirmed hepatocyte nuclear factor-1 α mutation on chromosome 12. Further oral treatment and attention to lifestyle modification improved control avoiding insulin therapy.

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Year:  2012        PMID: 22665711      PMCID: PMC4542727          DOI: 10.1136/bcr.11.2011.5127

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  9 in total

Review 1.  Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young.

Authors:  S S Fajans; G I Bell; K S Polonsky
Journal:  N Engl J Med       Date:  2001-09-27       Impact factor: 91.245

Review 2.  Clinical review: Type 1 diabetes and latent autoimmune diabetes in adults: one end of the rainbow.

Authors:  R David G Leslie; Rhys Williams; Paolo Pozzilli
Journal:  J Clin Endocrinol Metab       Date:  2006-02-14       Impact factor: 5.958

3.  Diagnosis and classification of diabetes mellitus.

Authors: 
Journal:  Diabetes Care       Date:  2008-01       Impact factor: 19.112

4.  A difference between the inheritance of classical juvenile-onset and maturity-onset type diabetes of young people.

Authors:  R B Tattersall; S S Fajans
Journal:  Diabetes       Date:  1975-01       Impact factor: 9.461

5.  Diagnostic heterogeneity of diabetes in lean young adults: classification based on immunological and genetic parameters.

Authors:  P Dussoix; M Vaxillaire; P B Iynedjian; J M Tiercy; J Ruiz; G A Spinas; W Berger; G Zahnd; P Froguel; J Philippe
Journal:  Diabetes       Date:  1997-04       Impact factor: 9.461

6.  Relationship of family history of type 2 diabetes, hypoglycemia, and autoantibodies to weight gain and lipids with intensive and conventional therapy in the Diabetes Control and Complications Trial.

Authors:  Jonathan Q Purnell; Raj K Dev; Michael W Steffes; Patricia A Cleary; Jerry P Palmer; Irl B Hirsch; John E Hokanson; John D Brunzell
Journal:  Diabetes       Date:  2003-10       Impact factor: 9.461

Review 7.  Latent autoimmune diabetes in adults.

Authors:  Ramachandra G Naik; Barbara M Brooks-Worrell; Jerry P Palmer
Journal:  J Clin Endocrinol Metab       Date:  2009-10-16       Impact factor: 5.958

8.  Antibodies to glutamic acid decarboxylase reveal latent autoimmune diabetes mellitus in adults with a non-insulin-dependent onset of disease.

Authors:  T Tuomi; L C Groop; P Z Zimmet; M J Rowley; W Knowles; I R Mackay
Journal:  Diabetes       Date:  1993-02       Impact factor: 9.461

9.  A genome-wide scan in families with maturity-onset diabetes of the young: evidence for further genetic heterogeneity.

Authors:  Timothy M Frayling; Cecilia M Lindgren; Jean Claude Chevre; Stephan Menzel; Marie Wishart; Yamina Benmezroua; Alison Brown; Julie C Evans; Pamidghantam Subba Rao; Christian Dina; Cécile Lecoeur; Timo Kanninen; Peter Almgren; Michael P Bulman; Youxiang Wang; James Mills; Rosemarie Wright-Pascoe; Melanie M Mahtani; Francesco Prisco; Angels Costa; Ignacio Cognet; Torben Hansen; Oluf Pedersen; Sian Ellard; Tiinamaija Tuomi; Leif C Groop; Philippe Froguel; Andrew T Hattersley; Martine Vaxillaire
Journal:  Diabetes       Date:  2003-03       Impact factor: 9.461

  9 in total

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