OBJECTIVE: A new classification of primary progressive aphasia (PPA) was recently proposed to differentiate between non-fluent aphasia (NF-PPA), semantic variant of PPA (S-PPA) and logopenic aphasia (LPA) by their phenotypic presentations. CSF biomarkers (BM) may differentiate PPA with atypical Alzheimer's disease (AD) that presents with LPA from PPA with frontotemporal lobe degeneration that presents with either NF-PPA or S-PPA. Single photon emission computed tomography (SPECT) was used to investigate brain hypoperfusion differences among PPA subtypes according to their CSF AD profiles. METHODS: 34 PPA patients underwent lumbar puncture and brain perfusion SPECT. PPA patients were classified into two subgroups according to the Aβ(42):tau ratio: PPA BM positive (with an AD CSF profile) and PPA BM negative (not having an AD CSF profile). The biological classification was made while blind to the phenotypical presentation. The brain perfusion profiles of the PPA subgroups were compared with those of 24 healthy subjects. RESULTS: PPA BM positive patients had left-side predominant hypoperfusion in the temporoparietal cortex that extended to the dorsolateral prefrontal cortex and perisylvian region while PPA BM negative patients had hypoperfusion that was predominant in the temporal poles (p<10(-4) corrected). CONCLUSION: Distinct hypoperfusion patterns in PPA BM positive and PPA BM negative patients were observed, similar to those that have been described for S-PPA and LPA. These results support using CSF biomarkers to classify PPA.
OBJECTIVE: A new classification of primary progressive aphasia (PPA) was recently proposed to differentiate between non-fluent aphasia (NF-PPA), semantic variant of PPA (S-PPA) and logopenic aphasia (LPA) by their phenotypic presentations. CSF biomarkers (BM) may differentiate PPA with atypical Alzheimer's disease (AD) that presents with LPA from PPA with frontotemporal lobe degeneration that presents with either NF-PPA or S-PPA. Single photon emission computed tomography (SPECT) was used to investigate brain hypoperfusion differences among PPA subtypes according to their CSF AD profiles. METHODS: 34 PPA patients underwent lumbar puncture and brain perfusion SPECT. PPA patients were classified into two subgroups according to the Aβ(42):tau ratio: PPA BM positive (with an AD CSF profile) and PPA BM negative (not having an AD CSF profile). The biological classification was made while blind to the phenotypical presentation. The brain perfusion profiles of the PPA subgroups were compared with those of 24 healthy subjects. RESULTS: PPA BM positive patients had left-side predominant hypoperfusion in the temporoparietal cortex that extended to the dorsolateral prefrontal cortex and perisylvian region while PPA BM negative patients had hypoperfusion that was predominant in the temporal poles (p<10(-4) corrected). CONCLUSION: Distinct hypoperfusion patterns in PPA BM positive and PPA BM negative patients were observed, similar to those that have been described for S-PPA and LPA. These results support using CSF biomarkers to classify PPA.
Authors: Edmond Teng; Tritia R Yamasaki; Michelle Tran; Julia J Hsiao; David L Sultzer; Mario F Mendez Journal: Dement Geriatr Cogn Disord Date: 2013-12-31 Impact factor: 2.959
Authors: Alberto Villarejo-Galende; Sara Llamas-Velasco; Adolfo Gómez-Grande; Verónica Puertas-Martín; Israel Contador; Pilar Sarandeses; Marta González-Sánchez; Rocío Trincado; Patrick Pilkington; Sebastián Ruiz-Solis; David A Pérez-Martínez; Alejandro Herrero-San Martín Journal: J Neurol Date: 2016-11-04 Impact factor: 4.849
Authors: David Bergeron; Maria L Gorno-Tempini; Gil D Rabinovici; Miguel A Santos-Santos; William Seeley; Bruce L Miller; Yolande Pijnenburg; M Antoinette Keulen; Colin Groot; Bart N M van Berckel; Wiesje M van der Flier; Philip Scheltens; Jonathan D Rohrer; Jason D Warren; Jonathan M Schott; Nick C Fox; Raquel Sanchez-Valle; Oriol Grau-Rivera; Ellen Gelpi; Harro Seelaar; Janne M Papma; John C van Swieten; John R Hodges; Cristian E Leyton; Olivier Piguet; Emily J Rogalski; Marsel M Mesulam; Lejla Koric; Kristensen Nora; Jeéreémie Pariente; Bradford Dickerson; Ian R Mackenzie; Ging-Yuek R Hsiung; Serge Belliard; David J Irwin; David A Wolk; Murray Grossman; Matthew Jones; Jennifer Harris; David Mann; Julie S Snowden; Patricio Chrem-Mendez; Ismael L Calandri; Alejandra A Amengual; Carole Miguet-Alfonsi; Eloi Magnin; Giuseppe Magnani; Roberto Santangelo; Vincent Deramecourt; Florence Pasquier; Niklas Mattsson; Christer Nilsson; Oskar Hansson; Julia Keith; Mario Masellis; Sandra E Black; Jordi A Matías-Guiu; María-Nieves Cabrera-Martin; Claire Paquet; Julien Dumurgier; Marc Teichmann; Marie Sarazin; Michel Bottlaender; Bruno Dubois; Christopher C Rowe; Victor L Villemagne; Rik Vandenberghe; Elias Granadillo; Edmond Teng; Mario Mendez; Philipp T Meyer; Lars Frings; Alberto Lleó; Rafael Blesa; Juan Fortea; Sang Won Seo; Janine Diehl-Schmid; Timo Grimmer; Kristian Steen Frederiksen; Pascual Sánchez-Juan; Gaël Chételat; Willemijn Jansen; Rémi W Bouchard; Robert Jr Laforce; Pieter Jelle Visser; Rik Ossenkoppele Journal: Ann Neurol Date: 2018-11 Impact factor: 10.422