| Literature DB >> 22664130 |
Eda Canales1, Joseph S Carlson, Todd Appleby, Martijn Fenaux, Johnny Lee, Yang Tian, Neeraj Tirunagari, Melanie Wong, William J Watkins.
Abstract
The use of a tri-substituted acylhydrazine as an isostere of a tertiary amide was explored in a series of HCV NS5B thumb site II inhibitors. Direct replacement generated an analog with similar conformational and physicochemical properties. The series was extended to produce compounds with potent binding affinities and encouraging levels of cellular potency.Entities:
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Year: 2012 PMID： 22664130 DOI： 10.1016/j.bmcl.2012.05.025
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823