W Feng1, L Fu, J Liu, D Li. 1. Bone and Joint Department of the First Hospital, Jilin University, Jilin, China. doctorfengwei@126.com
Abstract
OBJECTIVE: The objective of this study was to investigate the distribution of α-galactosyl (α-Gal), major histocompatibility complex (MHC)-I, and MHC-II antigens on adult porcine bone tissue. METHODS: Distribution of α-Gal, MHC-I, and MHC-II antigens on porcine bone tissue were observed using immunohistochemistry. RESULTS: α-Gal, MHC-I xenogeneic antigens were extensively observed on the surface of bone marrow cells, osteocytes, osteoblasts, and Harversian canals; MHC-II antigens were mainly expressed on bone marrow cells. CONCLUSION: α-Gal, MHC-I, and MHC-II are the main xenogeneic antigens that must be deleted to avoid xenogeneic immune reactions against bone xenografts.
OBJECTIVE: The objective of this study was to investigate the distribution of α-galactosyl (α-Gal), major histocompatibility complex (MHC)-I, and MHC-II antigens on adult porcine bone tissue. METHODS: Distribution of α-Gal, MHC-I, and MHC-II antigens on porcine bone tissue were observed using immunohistochemistry. RESULTS: α-Gal, MHC-I xenogeneic antigens were extensively observed on the surface of bone marrow cells, osteocytes, osteoblasts, and Harversian canals; MHC-II antigens were mainly expressed on bone marrow cells. CONCLUSION: α-Gal, MHC-I, and MHC-II are the main xenogeneic antigens that must be deleted to avoid xenogeneic immune reactions against bone xenografts.
Authors: Daniel N Bracey; Thorsten M Seyler; Alexander H Jinnah; Mark O Lively; Jeffrey S Willey; Thomas L Smith; Mark E Van Dyke; Patrick W Whitlock Journal: J Funct Biomater Date: 2018-07-12