Literature DB >> 2266365

Platelet monoamine oxidase B activity in parkinsonian patients.

U Bonuccelli1, P Piccini, P Del Dotto, G M Pacifici, G U Corsini, A Muratorio.   

Abstract

Monoamine oxidase B (MAO B) plays a pivotal role in N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced Parkinsonism. An increased MAO B activity in platelets of patients with idiopathic Parkinson's disease (PD) is reported in this study. The possibility that high MAO B activity may represent a trait of vulnerability for PD by enhancing the neurotoxic effects of environmental compounds is discussed.

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Year:  1990        PMID: 2266365      PMCID: PMC488245          DOI: 10.1136/jnnp.53.10.854

Source DB:  PubMed          Journal:  J Neurol Neurosurg Psychiatry        ISSN: 0022-3050            Impact factor:   10.154


  20 in total

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Review 2.  Multiple forms of monoamine oxidase: fact and artefact.

Authors:  M D Houslay; K F Tipton
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3.  Parkinsonism: onset, progression and mortality.

Authors:  M M Hoehn; M D Yahr
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4.  Platelet monoamine oxidase in schizophrenia and manic-depressive illness.

Authors:  R H Belmaker; K Ebbesen; R Ebstein; R Rimon
Journal:  Br J Psychiatry       Date:  1976-09       Impact factor: 9.319

5.  Neurotransmitter abnormalities in patients with motor neuron disease.

Authors:  K Belendiuk; G W Belendiuk; D X Freedman; J P Antel
Journal:  Arch Neurol       Date:  1981-07

6.  Molecular biology of neurological and psychiatric disorders. I. Effect of parkinsonism, age, sex and L-dopa on platelet monoamine oxidase.

Authors:  E A Zeller; B Boshes; J Arbit; M Bieber; E R Blonsky; M Dolkart; S V Huprikar
Journal:  J Neural Transm       Date:  1976       Impact factor: 3.575

7.  Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: characterization and localization of receptor binding sites in rat and human brain.

Authors:  J A Javitch; G R Uhl; S H Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  1984-07       Impact factor: 11.205

8.  Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis.

Authors:  J W Langston; P Ballard; J W Tetrud; I Irwin
Journal:  Science       Date:  1983-02-25       Impact factor: 47.728

9.  Aminergic systems in Alzheimer's disease and Parkinson's disease.

Authors:  R J D'Amato; R M Zweig; P J Whitehouse; G L Wenk; H S Singer; R Mayeux; D L Price; S H Snyder
Journal:  Ann Neurol       Date:  1987-08       Impact factor: 10.422

10.  Central catecholamine metabolism in vivo and the cognitive and motor deficits in Parkinson's disease.

Authors:  J J Mann; M Stanley; R D Kaplan; J Sweeney; A Neophytides
Journal:  J Neurol Neurosurg Psychiatry       Date:  1983-10       Impact factor: 10.154

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5.  Altered platelet monoamine oxidase-B activity in idiopathic Parkinson's disease.

Authors:  Maroof Husain; Rakesh Shukla; Madhu Dikshit; Pradeep K Maheshwari; Devika Nag; Rikhab C Srimal; Prahlad K Seth; Vinay K Khanna
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6.  The Role of Platelets in the Stimulation of Neuronal Synaptic Plasticity, Electric Activity, and Oxidative Phosphorylation: Possibilities for New Therapy of Neurodegenerative Diseases.

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  6 in total

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