Literature DB >> 22663064

Asymmetric total synthesis of cladosporin and isocladosporin.

Huaiji Zheng1, Changgui Zhao, Bowen Fang, Peng Jing, Juan Yang, Xingang Xie, Xuegong She.   

Abstract

The first asymmetric total syntheses of cladosporin and isocladosporin were accomplished in 8 steps with 8% overall yield and 10 steps with 26% overall yield, respectively. The relative configuration of isocladosporin was determined via this total synthesis.

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Year:  2012        PMID： 22663064     DOI： 10.1021/jo300805n

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  7 in total

1.  Production of New Cladosporin Analogues by Reconstitution of the Polyketide Synthases Responsible for the Biosynthesis of this Antimalarial Agent.

Authors:  Rachel V K Cochrane; Randy Sanichar; Gareth R Lambkin; Béla Reiz; Wei Xu; Yi Tang; John C Vederas
Journal:  Angew Chem Int Ed Engl       Date:  2015-11-24       Impact factor: 15.336

2.  Large-scale total synthesis of 13C3-labeled citrinin and its metabolite dihydrocitrinone.

Authors:  Dominik Bergmann; Florian Hübner; Birgit Wibbeling; Constantin Daniliuc; Benedikt Cramer; Hans-Ulrich Humpf
Journal:  Mycotoxin Res       Date:  2018-02-13       Impact factor: 3.833

3.  The growing pipeline of natural aminoacyl-tRNA synthetase inhibitors for malaria treatment.

Authors:  Adélaïde Saint-Léger; Christopher Sinadinos; Lluís Ribas de Pouplana
Journal:  Bioengineered       Date:  2016-03-10       Impact factor: 3.269

4.  Structural basis of malaria parasite lysyl-tRNA synthetase inhibition by cladosporin.

Authors:  Sameena Khan; Arvind Sharma; Hassan Belrhali; Manickam Yogavel; Amit Sharma
Journal:  J Struct Funct Genomics       Date:  2014-06-17

5.  Protein Translation Enzyme lysyl-tRNA Synthetase Presents a New Target for Drug Development against Causative Agents of Loiasis and Schistosomiasis.

Authors:  Arvind Sharma; Manmohan Sharma; Manickam Yogavel; Amit Sharma
Journal:  PLoS Negl Trop Dis       Date:  2016-11-02

6.  Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.

Authors:  Beatriz Baragaña; Barbara Forte; Ryan Choi; Stephen Nakazawa Hewitt; Juan A Bueren-Calabuig; João Pedro Pisco; Caroline Peet; David M Dranow; David A Robinson; Chimed Jansen; Neil R Norcross; Sumiti Vinayak; Mark Anderson; Carrie F Brooks; Caitlin A Cooper; Sebastian Damerow; Michael Delves; Karen Dowers; James Duffy; Thomas E Edwards; Irene Hallyburton; Benjamin G Horst; Matthew A Hulverson; Liam Ferguson; María Belén Jiménez-Díaz; Rajiv S Jumani; Donald D Lorimer; Melissa S Love; Steven Maher; Holly Matthews; Case W McNamara; Peter Miller; Sandra O'Neill; Kayode K Ojo; Maria Osuna-Cabello; Erika Pinto; John Post; Jennifer Riley; Matthias Rottmann; Laura M Sanz; Paul Scullion; Arvind Sharma; Sharon M Shepherd; Yoko Shishikura; Frederick R C Simeons; Erin E Stebbins; Laste Stojanovski; Ursula Straschil; Fabio K Tamaki; Jevgenia Tamjar; Leah S Torrie; Amélie Vantaux; Benoît Witkowski; Sergio Wittlin; Manickam Yogavel; Fabio Zuccotto; Iñigo Angulo-Barturen; Robert Sinden; Jake Baum; Francisco-Javier Gamo; Pascal Mäser; Dennis E Kyle; Elizabeth A Winzeler; Peter J Myler; Paul G Wyatt; David Floyd; David Matthews; Amit Sharma; Boris Striepen; Christopher D Huston; David W Gray; Alan H Fairlamb; Andrei V Pisliakov; Chris Walpole; Kevin D Read; Wesley C Van Voorhis; Ian H Gilbert
Journal:  Proc Natl Acad Sci U S A       Date:  2019-03-20       Impact factor: 11.205

7.  Experimental and Computational Investigations of the Reactions between α,β-Unsaturated Lactones and 1,3-Dienes by Cooperative Lewis Acid/Brønsted Acid Catalysis.

Authors:  Anja Weber; Martin Breugst; Jörg Pietruszka
Journal:  Angew Chem Int Ed Engl       Date:  2020-08-18       Impact factor: 16.823
  7 in total

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