Literature DB >> 22662315

Impaired dendritic expression and plasticity of h-channels in the fmr1(-/y) mouse model of fragile X syndrome.

Darrin H Brager1, Arvin R Akhavan, Daniel Johnston.   

Abstract

Despite extensive research into both synaptic and morphological changes, surprisingly little is known about dendritic function in fragile X syndrome (FXS). We found that the dendritic input resistance of CA1 neurons was significantly lower in fmr1(-/y) versus wild-type mice. Consistent with elevated dendritic I(h), voltage sag, rebound, and resonance frequency were significantly higher and temporal summation was lower in the dendrites of fmr1(-/y) mice. Dendritic expression of the h-channel subunit HCN1, but not HCN2, was higher in the CA1 region of fmr1(-/y) mice. Interestingly, whereas mGluR-mediated persistent decreases in I(h) occurred in both wildtype and fmr1(-/y) mice, persistent increases in I(h) that occurred after LTP induction in wild-type mice were absent in fmr1(-/y) mice. Thus, chronic upregulation of dendritic I(h) in conjunction with impairment of homeostatic h-channel plasticity represents a dendritic channelopathy in this model of mental retardation and may provide a mechanism for the cognitive impairment associated with FXS.

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Year:  2012        PMID： 22662315      PMCID： PMC3363364          DOI： 10.1016/j.celrep.2012.02.002

Source DB:  PubMed          Journal:  Cell Rep            Impact factor:   9.423


  33 in total

Review 1.  Resonance, oscillation and the intrinsic frequency preferences of neurons.

Authors:  B Hutcheon; Y Yarom
Journal:  Trends Neurosci       Date:  2000-05       Impact factor: 13.837

2.  Molecular and functional heterogeneity of hyperpolarization-activated pacemaker channels in the mouse CNS.

Authors:  B Santoro; S Chen; A Luthi; P Pavlidis; G P Shumyatsky; G R Tibbs; S A Siegelbaum
Journal:  J Neurosci       Date:  2000-07-15       Impact factor: 6.167

3.  Pharmacological upregulation of h-channels reduces the excitability of pyramidal neuron dendrites.

Authors:  Nicholas P Poolos; Michele Migliore; Daniel Johnston
Journal:  Nat Neurosci       Date:  2002-08       Impact factor: 24.884

4.  Homeostatic scaling of neuronal excitability by synaptic modulation of somatic hyperpolarization-activated Ih channels.

Authors:  Ingrid van Welie; Johannes A van Hooft; Wytse J Wadman
Journal:  Proc Natl Acad Sci U S A       Date:  2004-03-29       Impact factor: 11.205

5.  Altered synaptic plasticity in a mouse model of fragile X mental retardation.

Authors:  Kimberly M Huber; Sean M Gallagher; Stephen T Warren; Mark F Bear
Journal:  Proc Natl Acad Sci U S A       Date:  2002-05-28       Impact factor: 11.205

6.  Bidirectional regulation of dendritic voltage-gated potassium channels by the fragile X mental retardation protein.

Authors:  Hye Young Lee; Woo-Ping Ge; Wendy Huang; Ye He; Gordon X Wang; Ashley Rowson-Baldwin; Stephen J Smith; Yuh Nung Jan; Lily Yeh Jan
Journal:  Neuron       Date:  2011-11-17       Impact factor: 17.173

7.  Acquired dendritic channelopathy in temporal lobe epilepsy.

Authors:  Christophe Bernard; Anne Anderson; Albert Becker; Nicholas P Poolos; Heinz Beck; Daniel Johnston
Journal:  Science       Date:  2004-07-23       Impact factor: 47.728

8.  Hyperpolarization-activated current Ih disconnects somatic and dendritic spike initiation zones in layer V pyramidal neurons.

Authors:  Thomas Berger; Walter Senn; Hans-R Lüscher
Journal:  J Neurophysiol       Date:  2003-06-11       Impact factor: 2.714

9.  Contribution of Ih and GABAB to synaptically induced afterhyperpolarizations in CA1: a brake on the NMDA response.

Authors:  Nonna A Otmakhova; John E Lisman
Journal:  J Neurophysiol       Date:  2004-05-26       Impact factor: 2.714

10.  The fragile X syndrome protein FMRP associates with BC1 RNA and regulates the translation of specific mRNAs at synapses.

Authors:  Francesca Zalfa; Marcello Giorgi; Beatrice Primerano; Annamaria Moro; Alessandra Di Penta; Surya Reis; Ben Oostra; Claudia Bagni
Journal:  Cell       Date:  2003-02-07       Impact factor: 41.582
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  51 in total

1.  Short- and long-term plasticity in CA1 neurons from mice lacking h-channel auxiliary subunit TRIP8b.

Authors:  Darrin H Brager; Alan S Lewis; Dane M Chetkovich; Daniel Johnston
Journal:  J Neurophysiol       Date:  2013-08-21       Impact factor: 2.714

2.  HCN channels enhance spike phase coherence and regulate the phase of spikes and LFPs in the theta-frequency range.

Authors:  Manisha Sinha; Rishikesh Narayanan
Journal:  Proc Natl Acad Sci U S A       Date:  2015-04-13       Impact factor: 11.205

Review 3.  Altered Neuronal and Circuit Excitability in Fragile X Syndrome.

Authors:  Anis Contractor; Vitaly A Klyachko; Carlos Portera-Cailliau
Journal:  Neuron       Date:  2015-08-19       Impact factor: 17.173

4.  Loss of functional A-type potassium channels in the dendrites of CA1 pyramidal neurons from a mouse model of fragile X syndrome.

Authors:  Brandy N Routh; Daniel Johnston; Darrin H Brager
Journal:  J Neurosci       Date:  2013-12-11       Impact factor: 6.167

Review 5.  Ion channels in genetic and acquired forms of epilepsy.

Authors:  Holger Lerche; Mala Shah; Heinz Beck; Jeff Noebels; Dan Johnston; Angela Vincent
Journal:  J Physiol       Date:  2012-10-22       Impact factor: 5.182

6.  HCN channels are a novel therapeutic target for cognitive dysfunction in Neurofibromatosis type 1.

Authors:  A Omrani; T van der Vaart; E Mientjes; G M van Woerden; M R Hojjati; K W Li; D H Gutmann; C N Levelt; A B Smit; A J Silva; S A Kushner; Y Elgersma
Journal:  Mol Psychiatry       Date:  2015-04-28       Impact factor: 15.992

7.  Fragile X Mental Retardation Protein Bidirectionally Controls Dendritic Ih in a Cell Type-Specific Manner between Mouse Hippocampus and Prefrontal Cortex.

Authors:  Federico Brandalise; Brian E Kalmbach; Preeti Mehta; Olivia Thornton; Daniel Johnston; Boris V Zemelman; Darrin H Brager
Journal:  J Neurosci       Date:  2020-05-28       Impact factor: 6.167

8.  Store depletion-induced h-channel plasticity rescues a channelopathy linked to Alzheimer's disease.

Authors:  Timothy F Musial; Elizabeth Molina-Campos; Linda A Bean; Natividad Ybarra; Ronen Borenstein; Matthew L Russo; Eric W Buss; Daniel Justus; Krystina M Neuman; Gelique D Ayala; Sheila A Mullen; Yuliya Voskobiynyk; Christopher T Tulisiak; Jasmine A Fels; Nicola J Corbett; Gabriel Carballo; Colette D Kennedy; Jelena Popovic; Josefina Ramos-Franco; Michael Fill; Melissa R Pergande; Jeffrey A Borgia; Grant T Corbett; Kalipada Pahan; Ye Han; Dane M Chetkovich; Robert J Vassar; Richard W Byrne; M Matthew Oh; Travis R Stoub; Stefan Remy; John F Disterhoft; Daniel A Nicholson
Journal:  Neurobiol Learn Mem       Date:  2018-06-12       Impact factor: 2.877

Review 9.  Channelopathies and dendritic dysfunction in fragile X syndrome.

Authors:  Darrin H Brager; Daniel Johnston
Journal:  Brain Res Bull       Date:  2014-01-23       Impact factor: 4.077

10.  Increased Persistent Sodium Current Causes Neuronal Hyperexcitability in the Entorhinal Cortex of Fmr1 Knockout Mice.

Authors:  Pan-Yue Deng; Vitaly A Klyachko
Journal:  Cell Rep       Date:  2016-09-20       Impact factor: 9.423
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