HYPOTHESIS: Although smoking is the major risk factor for non-small-cell lung cancer (NSCLC), other factors are also associated with lung carcinogenesis, such as wood-smoke exposure (WSE). This article has been aimed at suggesting that lung cancer related to cigarette smoking and lung cancer related to WSE have different clinical and genetic characteristics. EXPERIMENTAL DESIGN: A cohort of 914 lung cancer patients was prospectively studied; they had been treated at Mexico's National Cancer Institute between 2007 and 2010. The associations of WSE and cigarette smoking with clinical characteristics, mutation profile, response to chemotherapy, and epidermal growth factor receptor tyrosine kinase inhibitors were analyzed, and overall survival (OS) rate was calculated. The trial was registered with ClinicalTrials.gov: NCT01023828. RESULTS: Of the lung cancer patients studied, 95.1% were classified as coming within the NSCLC histology subtype; 58% of the patients smoked cigarettes, 35% had a background of WSE (exposure to both cigarette smoke and wood smoke was documented in 12.1% of all patients), and 19.4% patients had no smoke-exposure background. WSE was associated with NSCLC and adenocarcinoma histology, and was also more frequently associated with epidermal growth factor receptor-mutations than cigarette-smoking patients were (50.0% cf. 19.4%), whereas KRAS mutations were less common in WSE patients (6.7%) than in smokers (21%). WSE patients had a higher epidermal growth factor receptor tyrosine kinase inhibitor response rate (39.7%) than smokers (18.8%). The NSCLC patient WSE group's OS was longer (22.7 months) than that for smokers (13.8 months). CONCLUSION: NSCLC patients who smoked tobacco/cigarettes differed from those having a background of WSE regarding tumor histology, mutation profile, response rate, and OS, indicating that different carcinogenic mechanisms were induced by these two types of smoke exposure.
HYPOTHESIS: Although smoking is the major risk factor for non-small-cell lung cancer (NSCLC), other factors are also associated with lung carcinogenesis, such as wood-smoke exposure (WSE). This article has been aimed at suggesting that lung cancer related to cigarette smoking and lung cancer related to WSE have different clinical and genetic characteristics. EXPERIMENTAL DESIGN: A cohort of 914 lung cancerpatients was prospectively studied; they had been treated at Mexico's National Cancer Institute between 2007 and 2010. The associations of WSE and cigarette smoking with clinical characteristics, mutation profile, response to chemotherapy, and epidermal growth factor receptor tyrosine kinase inhibitors were analyzed, and overall survival (OS) rate was calculated. The trial was registered with ClinicalTrials.gov: NCT01023828. RESULTS: Of the lung cancerpatients studied, 95.1% were classified as coming within the NSCLC histology subtype; 58% of the patients smoked cigarettes, 35% had a background of WSE (exposure to both cigarette smoke and wood smoke was documented in 12.1% of all patients), and 19.4% patients had no smoke-exposure background. WSE was associated with NSCLC and adenocarcinoma histology, and was also more frequently associated with epidermal growth factor receptor-mutations than cigarette-smoking patients were (50.0% cf. 19.4%), whereas KRAS mutations were less common in WSE patients (6.7%) than in smokers (21%). WSE patients had a higher epidermal growth factor receptor tyrosine kinase inhibitor response rate (39.7%) than smokers (18.8%). The NSCLCpatient WSE group's OS was longer (22.7 months) than that for smokers (13.8 months). CONCLUSION:NSCLCpatients who smoked tobacco/cigarettes differed from those having a background of WSE regarding tumor histology, mutation profile, response rate, and OS, indicating that different carcinogenic mechanisms were induced by these two types of smoke exposure.
Authors: Sofia Palacio; Luciola Pontes; Edna Prado; Junaid Arshad; Robert Ali; Tony Piha; Carlos Eduardo Bacchi; Raja Mudad; Gilberto Lopes Journal: Oncologist Date: 2018-11-16
Authors: Oscar Arrieta; Pablo Anaya; Vicente Morales-Oyarvide; Laura Alejandra Ramírez-Tirado; Ana C Polanco Journal: Eur J Health Econ Date: 2015-09-04
Authors: J Smith Torres-Roman; Bryan Valcarcel; Jose Fabian Martinez-Herrera; Janina Bazalar-Palacios; Carlo La Vecchia; Luis E Raez Journal: Asian Pac J Cancer Prev Date: 2022-02-01
Authors: Oscar Arrieta; Roger Humberto Quintana-Carrillo; Gabriel Ahumada-Curiel; Jose Francisco Corona-Cruz; Elma Correa-Acevedo; Juan Zinser-Sierra; Dolores de la Mata-Moya; Alejandro Mohar-Betancourt; Vicente Morales-Oyarvide; Luz Myriam Reynales-Shigematsu Journal: Tob Induc Dis Date: 2015-02-04 Impact factor: 2.600