| Literature DB >> 22658536 |
S M Abdur Rahman1, Takeshi Baba, Tetsuya Kodama, Md Ariful Islam, Satoshi Obika.
Abstract
Various stereochemically pure cationic phosphorothioate oligonucleotides bearing aminoalkyl moieties were synthesized, and their duplex-forming ability against single-stranded DNA (ssDNA), single-stranded RNA (ssRNA) and triplex-forming ability against double-stranded DNA (dsDNA) were evaluated by UV melting experiments. The cationic Rp stereoisomers showed improved duplex-forming ability against ssDNA, triplex-forming ability against dsDNA and nuclease stability.Entities:
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Year: 2012 PMID： 22658536 DOI： 10.1016/j.bmc.2012.05.009
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641