Literature DB >> 22658480

Transformation of primary myelofibrosis with 20q- in Philadelphia-positive acute lymphoblastic leukemia: case report and review of literature.

Vladimir Jurisic1, Natasa Colovic, Tatjana Terzic, Vesna Djordjevic, Milica Colovic.   

Abstract

A 56-year-old male with chronic idiopathic myelofibrosis and cytogenetic finding of 20q- after a period of 10 months developed acute Philadelphia-positive lymphoblastic leukemia. Immunophenotyping of peripheral blood by flow cytometry showed HLA-DR, CD34, CD19, CD22, CD10, CD33, and CD11b positivity. Cytogenetic analysis revealed the presence of 20q- and Philadelphia chromosome t(9;22)(q34:q11) at the time of disease transformation to ALL. The JAK2V617F mutation was not found. This is a very rare case of simultaneous presence of two cytogenetics abnormalities and evolution of primary idiopathic myelofibrosis to Philadelphia-positive acute lymphoblastic leukemia.
Copyright © 2012 Elsevier GmbH. All rights reserved.

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Year:  2012        PMID： 22658480     DOI： 10.1016/j.prp.2012.04.007

Source DB:  PubMed          Journal:  Pathol Res Pract        ISSN： 0344-0338            Impact factor:   3.250


  4 in total

1.  Possibility of transformation of primary myelofibrosis to ALL without JAK2V617F mutation.

Authors:  Vladimir Jurisic; Sonja Pavlovic; Natasa Colovic; Milica Colovic
Journal:  Med Oncol       Date:  2013-01-08       Impact factor: 3.064

2.  Acute Lymphoblastic Leukemia Arising in CALR Mutated Essential Thrombocythemia.

Authors:  Stephen E Langabeer; Karl Haslam; David O'Brien; Johanna Kelly; Claire Andrews; Ciara Ryan; Richard Flavin; Patrick J Hayden; Christopher L Bacon
Journal:  Case Rep Hematol       Date:  2016-01-21

3.  Acute lymphoblastic leukemia secondary to myeloproliferative neoplasms or after lenalidomide exposure.

Authors:  Ahmad Alhuraiji; Kiran Naqvi; Yang O Huh; Coty Ho; Srdan Verstovsek; Prithviraj Bose
Journal:  Clin Case Rep       Date:  2017-12-06

4.  A case of minor BCR-ABL1 positive acute lymphoblastic leukemia following essential thrombocythemia and originating from a clone distinct from that harboring the JAK2-V617F mutation.

Authors:  Yuya Nagai; Masahiro Kawahara; Noriko Sugino; Yayoi Shimazu; Masakatsu Hishizawa; Kouhei Yamashita; Norimitsu Kadowaki; Akifumi Takaori-Kondo
Journal:  Exp Hematol Oncol       Date:  2014-02-17
  4 in total

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