| Literature DB >> 22658363 |
Kashmiri Lal1, Ashwani Kumar, M S Pavan, C P Kaushik.
Abstract
A series of 1,4-disubstituted 1,2,3-bistriazoles was synthesized via click chemistry by cycloaddition of various bisalkynes with benzyl/2-phenylethyl azide. Synthesized triazoles were characterized by IR, (1)H NMR, (13)C NMR and mass spectral techniques. All the compounds were evaluated for antibacterial/antifungal activities and found to possess moderate to good antimicrobial activities. Further the docking study for the most active compound against DNA Gyrase was also carried out.Entities:
Mesh：
Substances：
Year: 2012 PMID： 22658363 DOI： 10.1016/j.bmcl.2012.05.008
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823