OBJECTIVE: Obesity and overweight are related to unfavourable lipoprotein subclass profiles. Here we studied the relation between weight change and lipoprotein particle concentrations and sizes in a general population cohort in a longitudinal setting. METHODS: The cohort included 683 adults with a 6.5-year follow-up. Lipoprotein particle subclasses and mean particle sizes of VLDL, LDL, and HDL were measured by nuclear magnetic resonance spectroscopy. RESULTS: During the follow-up period, a weight loss of at least 5% was associated with decreased particle concentrations of all apoB-containing subclasses and increased concentrations of large HDL particles. Coherently, weight gain (≥5%) was associated with increases in all apoB-containing subclasses and decreases in total and medium HDL particle concentrations. The relatively largest increase occurred for large HDL particle concentration (24.1%, 95% CI 15.8-32.5) in weight loss and for large VLDL particle concentration (33.0%, 19.6-46.4) in weight gain. Weight change correlated positively with changes in apoB-containing lipoprotein particle concentrations and also with the change in average VLDL particle size. Negative correlations were found between weight change and the change in average LDL (r = -0.10) and HDL (r = -0.32) particle size, but not between weight change and total HDL particle concentration. CONCLUSION: Moderate weight loss is related to favourable and weight gain to unfavourable changes in lipoprotein subclass profiles. These population level findings underline the importance of weight control as a modifier of cardiovascular risk factors.
OBJECTIVE: Obesity and overweight are related to unfavourable lipoprotein subclass profiles. Here we studied the relation between weight change and lipoprotein particle concentrations and sizes in a general population cohort in a longitudinal setting. METHODS: The cohort included 683 adults with a 6.5-year follow-up. Lipoprotein particle subclasses and mean particle sizes of VLDL, LDL, and HDL were measured by nuclear magnetic resonance spectroscopy. RESULTS: During the follow-up period, a weight loss of at least 5% was associated with decreased particle concentrations of all apoB-containing subclasses and increased concentrations of large HDL particles. Coherently, weight gain (≥5%) was associated with increases in all apoB-containing subclasses and decreases in total and medium HDL particle concentrations. The relatively largest increase occurred for large HDL particle concentration (24.1%, 95% CI 15.8-32.5) in weight loss and for large VLDL particle concentration (33.0%, 19.6-46.4) in weight gain. Weight change correlated positively with changes in apoB-containing lipoprotein particle concentrations and also with the change in average VLDL particle size. Negative correlations were found between weight change and the change in average LDL (r = -0.10) and HDL (r = -0.32) particle size, but not between weight change and total HDL particle concentration. CONCLUSION: Moderate weight loss is related to favourable and weight gain to unfavourable changes in lipoprotein subclass profiles. These population level findings underline the importance of weight control as a modifier of cardiovascular risk factors.
Authors: Simone Wahl; Susanne Vogt; Ferdinand Stückler; Jan Krumsiek; Jörg Bartel; Tim Kacprowski; Katharina Schramm; Maren Carstensen; Wolfgang Rathmann; Michael Roden; Carolin Jourdan; Antti J Kangas; Pasi Soininen; Mika Ala-Korpela; Ute Nöthlings; Heiner Boeing; Fabian J Theis; Christa Meisinger; Melanie Waldenberger; Karsten Suhre; Georg Homuth; Christian Gieger; Gabi Kastenmüller; Thomas Illig; Jakob Linseisen; Annette Peters; Holger Prokisch; Christian Herder; Barbara Thorand; Harald Grallert Journal: BMC Med Date: 2015-03-09 Impact factor: 8.775
Authors: Line K Johnson; Kirsten B Holven; Njord Nordstrand; Jan R Mellembakken; Tom Tanbo; Jøran Hjelmesæth Journal: Endocr Connect Date: 2015-09 Impact factor: 3.335
Authors: Sophie Schutte; Diederik Esser; Els Siebelink; Charlotte J R Michielsen; Monique Daanje; Juri C Matualatupauw; Hendriek C Boshuizen; Marco Mensink; Lydia A Afman Journal: Am J Clin Nutr Date: 2022-07-06 Impact factor: 8.472