Literature DB >> 22654707

Hereditary multiple exostoses in the hands and fingers: early presentation and early surgical treatment in family members. Case reports.

Rika Ohkuma, Edward F McCarthy, E Gene Deune.   

Abstract

Hereditary multiple exostosis (HME) is a benign condition with multiple bony tumors with cartilage caps (osteochondromas), mainly presenting in the long and flat bones. Usually the presentation for HME is between 2 and 10 years of age and most are seen by 4 years of age (Khan et al. 2009). In this paper, we report a family with three members (father, son, and a daughter) who had very early presentations of HME in the fingers within the first 2 years of age. The son presented with bony nodules at 7 months of age, and he required surgery at 13 months of age for a severe functional deformity of his left ring finger. He also had an unusual histological presentation on his osteochondroma that consists of only subperiosteal cartilage without ossification.

Entities:  

Keywords:  Early presentation; Hand; Hereditary multiple exostoses; Osteochondroma

Year:  2010        PMID: 22654707      PMCID: PMC3092885          DOI: 10.1007/s11552-010-9307-3

Source DB:  PubMed          Journal:  Hand (N Y)        ISSN: 1558-9447


  42 in total

1.  Tumors of the hand.

Authors:  J L POSCH
Journal:  J Bone Joint Surg Am       Date:  1956-06       Impact factor: 5.284

2.  Chondrosarcoma, a surgical and pathological problem; review of 212 cases.

Authors:  D C DAHLIN; E D HENDERSON
Journal:  J Bone Joint Surg Am       Date:  1956-10       Impact factor: 5.284

3.  Hereditary multiple exostoses. Anthropometric, roentgenographic, and clinical aspects.

Authors:  F Shapiro; S Simon; M J Glimcher
Journal:  J Bone Joint Surg Am       Date:  1979-09       Impact factor: 5.284

4.  Genotype-phenotype correlation in hereditary multiple exostoses.

Authors:  C Francannet; A Cohen-Tanugi; M Le Merrer; A Munnich; J Bonaventure; L Legeai-Mallet
Journal:  J Med Genet       Date:  2001-07       Impact factor: 6.318

5.  The natural history of hereditary multiple exostoses.

Authors:  G A Schmale; E U Conrad; W H Raskind
Journal:  J Bone Joint Surg Am       Date:  1994-07       Impact factor: 5.284

6.  Calcaneal osteochondroma.

Authors:  Ryan Skinner; Douglas P Beall; Heather R Webb; Justin Q Ly; Jon R Fish
Journal:  J Okla State Med Assoc       Date:  2007-04

7.  Cloning of the putative tumour suppressor gene for hereditary multiple exostoses (EXT1).

Authors:  J Ahn; H J Lüdecke; S Lindow; W A Horton; B Lee; M J Wagner; B Horsthemke; D E Wells
Journal:  Nat Genet       Date:  1995-10       Impact factor: 38.330

8.  Osteocartilaginous lesions of the digits in children: an experience with 10 cases.

Authors:  J R Moore; R M Curtis; E F Wilgis
Journal:  J Hand Surg Am       Date:  1983-05       Impact factor: 2.230

9.  A gene for hereditary multiple exostoses maps to chromosome 19p.

Authors:  M Le Merrer; L Legeai-Mallet; P M Jeannin; B Horsthemke; A Schinzel; H Plauchu; A Toutain; F Achard; A Munnich; P Maroteaux
Journal:  Hum Mol Genet       Date:  1994-05       Impact factor: 6.150

10.  Osteochondromas of the hand in hereditary multiple exostosis: report of a case presenting as a blocked proximal interphalangeal joint.

Authors:  M A Karr; P L Aulicino; T E DuPuy; F W Gwathmey
Journal:  J Hand Surg Am       Date:  1984-03       Impact factor: 2.230

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  1 in total

1.  A giant multi-lobed osteochondroma of the phalanx in an adult: A case report.

Authors:  Mohammad M Al-Qattan; Felwa Al-Marshad; Jumana Al-Shammari; Atif Rafique
Journal:  Int J Surg Case Rep       Date:  2016-12-27
  1 in total

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