Does antioxidant therapy influence every aspect of quality of life?

To present problems that might severely impact the conclusions drawn by the authors of an article on antioxidant treatment in chronic pancreatitis (World J Gastroenterol 2010; 16: 4066-4071). We analyzed and discussed this paper by Shah et al, and found that promising as it is, this study has some methodological shortcomings, such as: cross-sectional nature of the study, lack of initial evaluations of quality of life and regular follow-ups to determine the dynamics and real directions of changes in quality of life. We therefore concluded that the results of the study by Shah et al are biased and, although very promising, should not be considered as scientifically relevant.