| Literature DB >> 2265404 |
J R Teyssier1, F Liautaud-Roger, D Ferre, M Patey, J Dufer.
Abstract
A cytogenetic study was performed in 63 thyroid tumors after a monolayer short-term culture. Clonal chromosomal changes were found in 47% of carcinomas and 31% of adenomas. Chromosome 7 was altered in 40% of cytogenetically abnormal tumors. The modal DNA index measured in 26 tumors was consistent with the chromosomal mode in 88% of cases. A quantitative morphometric analysis of nuclear features differentiated between diploid thyroid adenomas with or without a single translocation, which suggests that they have different biological properties. Clonal chromosomal changes were observed in 78% of carcinomas with an aggressive behavior, but only 28% of those had no risk factors. The two patients who died early had abnormalities of chromosome 7.Entities:
Mesh：
Substances：
Year: 1990 PMID： 2265404 DOI： 10.1016/0165-4608(90)90184-c
Source DB: PubMed Journal: Cancer Genet Cytogenet ISSN： 0165-4608