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Literature DB >> 22653922

Echinocandin resistance due to simultaneous FKS mutation and increased cell wall chitin in a Candida albicans bloodstream isolate following brief exposure to caspofungin.

Toufeeq Imtiaz¹, Kathy K Lee², Carol A Munro², Donna M MacCallum², Gillian S Shankland³, Elizabeth M Johnson⁴, Mark S MacGregor¹, Abhijit M Bal¹.

Abstract

Echinocandins are first-line agents for treating severe invasive candidiasis. Glucan synthase gene (FKS1) mutations lead to echinocandin resistance but the role of enhanced chitin expression is not well recognized in clinical isolates. We report a case of bloodstream Candida albicans infection with both Fks1 hotspot mutation and elevated cell wall chitin.

Entities: Chemical Disease Species

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Year: 2012 PMID： 22653922 DOI： 10.1099/jmm.0.045047-0

Source DB: PubMed Journal: J Med Microbiol ISSN： 0022-2615 Impact factor: 2.472

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Cited

13 in total

1. Implication of Candida parapsilosis FKS1 and FKS2 mutations in reduced echinocandin susceptibility.

Authors: M Martí-Carrizosa; F Sánchez-Reus; F March; E Cantón; P Coll
Journal: Antimicrob Agents Chemother Date: 2015-03-16 Impact factor: 5.191

2. Epidemiology of echinocandin resistance in Candida.

Authors: Nina T Grossman; Tom M Chiller; Shawn R Lockhart
Journal: Curr Fungal Infect Rep Date: 2014-09-21

3. Tolerance to Caspofungin in Candida albicans Is Associated with at Least Three Distinctive Mechanisms That Govern Expression of FKS Genes and Cell Wall Remodeling.

Authors: Feng Yang; Lulu Zhang; Hironao Wakabayashi; Jason Myers; Yuanying Jiang; Yongbing Cao; Cristina Jimenez-Ortigosa; David S Perlin; Elena Rustchenko
Journal: Antimicrob Agents Chemother Date: 2017-04-24 Impact factor: 5.191

4. Impact of FKS1 Genotype on Echinocandin In Vitro Susceptibility in Candida auris and In Vivo Response in a Murine Model of Infection.

Authors: Dipti Sharma; Raees A Paul; Shivaprakash M Rudramurthy; Nisha Kashyap; Sanjay Bhattacharya; Rajeev Soman; Shamanth A Shankarnarayan; Dipali Chavan; Shreya Singh; Parijit Das; Harsimran Kaur; Anup K Ghosh; Rajendra Prasad; Kaustuv Sanyal; Arunaloke Chakrabarti
Journal: Antimicrob Agents Chemother Date: 2021-11-15 Impact factor: 5.938

5. Rapid screening method of Saccharomyces cerevisiae mutants using calcofluor white and aniline blue.

Authors: Francine Perrine-Walker; Jennifer Payne
Journal: Braz J Microbiol Date: 2021-05-04 Impact factor: 2.476

6. Inactivating the mannose-ethanolamine phosphotransferase Gpi7 confers caspofungin resistance in the human fungal pathogen Candida albicans.

Authors: Guisheng Zeng; Xiaoli Xu; Jiaxin Gao; Alessandra da Silva Dantas; Neil A R Gow; Yue Wang
Journal: Cell Surf Date: 2021-06-23

Echinocandin resistance due to simultaneous FKS mutation and increased cell wall chitin in a Candida albicans bloodstream isolate following brief exposure to caspofungin.

1. Implication of Candida parapsilosis FKS1 and FKS2 mutations in reduced echinocandin susceptibility.

2. Epidemiology of echinocandin resistance in Candida.

3. Tolerance to Caspofungin in Candida albicans Is Associated with at Least Three Distinctive Mechanisms That Govern Expression of FKS Genes and Cell Wall Remodeling.

4. Impact of FKS1 Genotype on Echinocandin In Vitro Susceptibility in Candida auris and In Vivo Response in a Murine Model of Infection.

5. Rapid screening method of Saccharomyces cerevisiae mutants using calcofluor white and aniline blue.

6. Inactivating the mannose-ethanolamine phosphotransferase Gpi7 confers caspofungin resistance in the human fungal pathogen Candida albicans.

Review 7. New antibiotic agents in the pipeline and how they can help overcome microbial resistance.

8. Cinnamomum zeylanicum bark essential oil induces cell wall remodelling and spindle defects in Candida albicans.

9. Yeast species-specific, differential inhibition of β-1,3-glucan synthesis by poacic acid and caspofungin.

10. A Mechanosensitive Channel Governs Lipid Flippase-Mediated Echinocandin Resistance in Cryptococcus neoformans.