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Literature DB >> 22653209

Vismodegib.

Andrzej Dlugosz, Sid Agrawal, Peter Kirkpatrick.

Abstract

Entities: Chemical Disease Gene Mutation Species

Mesh：

Substances：

Year: 2012 PMID： 22653209 PMCID： PMC3383648 DOI： 10.1038/nrd3753

Source DB: PubMed Journal: Nat Rev Drug Discov ISSN： 1474-1776 Impact factor: 84.694

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20 in total

1. Human homolog of patched, a candidate gene for the basal cell nevus syndrome.

Authors: R L Johnson; A L Rothman; J Xie; L V Goodrich; J W Bare; J M Bonifas; A G Quinn; R M Myers; D R Cox; E H Epstein; M P Scott
Journal: Science Date: 1996-06-14 Impact factor: 47.728

2. Inhibiting the hedgehog pathway in patients with the basal-cell nevus syndrome.

Authors: Jean Y Tang; Julian M Mackay-Wiggan; Michelle Aszterbaum; Robert L Yauch; Joselyn Lindgren; Kris Chang; Carol Coppola; Anita M Chanana; Jackleen Marji; David R Bickers; Ervin H Epstein
Journal: N Engl J Med Date: 2012-06-07 Impact factor: 91.245

Review 3. Basal cell carcinomas: attack of the hedgehog.

Authors: Ervin H Epstein
Journal: Nat Rev Cancer Date: 2008-10 Impact factor: 60.716

4. GDC-0449-a potent inhibitor of the hedgehog pathway.

Authors: Kirk D Robarge; Shirley A Brunton; Georgette M Castanedo; Yong Cui; Michael S Dina; Richard Goldsmith; Stephen E Gould; Oivin Guichert; Janet L Gunzner; Jason Halladay; Wei Jia; Cyrus Khojasteh; Michael F T Koehler; Karen Kotkow; Hank La; Rebecca L Lalonde; Kevin Lau; Leslie Lee; Derek Marshall; James C Marsters; Lesley J Murray; Changgeng Qian; Lee L Rubin; Laurent Salphati; Mark S Stanley; John H A Stibbard; Daniel P Sutherlin; Savita Ubhayaker; Shumei Wang; Susan Wong; Minli Xie
Journal: Bioorg Med Chem Lett Date: 2009-08-15 Impact factor: 2.823

5. Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome.

Authors: H Hahn; C Wicking; P G Zaphiropoulous; M R Gailani; S Shanley; A Chidambaram; I Vorechovsky; E Holmberg; A B Unden; S Gillies; K Negus; I Smyth; C Pressman; D J Leffell; B Gerrard; A M Goldstein; M Dean; R Toftgard; G Chenevix-Trench; B Wainwright; A E Bale
Journal: Cell Date: 1996-06-14 Impact factor: 41.582

6. Transient inhibition of the Hedgehog pathway in young mice causes permanent defects in bone structure.

Authors: Hiromichi Kimura; Jessica M Y Ng; Tom Curran
Journal: Cancer Cell Date: 2008-03 Impact factor: 31.743

7. Mutations affecting segment number and polarity in Drosophila.

Authors: C Nüsslein-Volhard; E Wieschaus
Journal: Nature Date: 1980-10-30 Impact factor: 49.962

8. Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449.

Authors: Charles M Rudin; Christine L Hann; John Laterra; Robert L Yauch; Christopher A Callahan; Ling Fu; Thomas Holcomb; Jeremy Stinson; Stephen E Gould; Barbara Coleman; Patricia M LoRusso; Daniel D Von Hoff; Frederic J de Sauvage; Jennifer A Low
Journal: N Engl J Med Date: 2009-09-02 Impact factor: 91.245

9. Inhibition of the hedgehog pathway in advanced basal-cell carcinoma.

Authors: Daniel D Von Hoff; Patricia M LoRusso; Charles M Rudin; Josina C Reddy; Robert L Yauch; Raoul Tibes; Glen J Weiss; Mitesh J Borad; Christine L Hann; Julie R Brahmer; Howard M Mackey; Bertram L Lum; Walter C Darbonne; James C Marsters; Frederic J de Sauvage; Jennifer A Low
Journal: N Engl J Med Date: 2009-09-02 Impact factor: 91.245

10. Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine.

Authors: J Taipale; J K Chen; M K Cooper; B Wang; R K Mann; L Milenkovic; M P Scott; P A Beachy
Journal: Nature Date: 2000-08-31 Impact factor: 49.962

45 in total

Review 1. Synthetic Small Molecule Inhibitors of Hh Signaling As Anti-Cancer Chemotherapeutics.

Authors: C A Maschinot; J R Pace; M K Hadden
Journal: Curr Med Chem Date: 2015 Impact factor: 4.530

Review 2. Hedgehog Signaling: From Basic Biology to Cancer Therapy.

Authors: Fujia Wu; Yu Zhang; Bo Sun; Andrew P McMahon; Yu Wang
Journal: Cell Chem Biol Date: 2017-03-09 Impact factor: 8.116

3. NHC-Copper Mediated Ligand-Directed Radiofluorination of Aryl Halides.

Authors: Liam S Sharninghausen; Allen F Brooks; Wade P Winton; Katarina J Makaravage; Peter J H Scott; Melanie S Sanford
Journal: J Am Chem Soc Date: 2020-04-10 Impact factor: 15.419

4. Targeted treatments for metastatic esophageal squamous cell cancer.

Authors: Antonia Digklia; Ioannis A Voutsadakis
Journal: World J Gastrointest Oncol Date: 2013-05-15

5. Combination therapy of prostate cancer with HPMA copolymer conjugates containing PI3K/mTOR inhibitor and docetaxel.

Authors: Yan Zhou; Jiyuan Yang; Rui Zhang; Jindřich Kopeček
Journal: Eur J Pharm Biopharm Date: 2014-12-03 Impact factor: 5.571

Review 6. MicroRNAs in liver fibrosis: Focusing on the interaction with hedgehog signaling.

Authors: Jeongeun Hyun; Youngmi Jung
Journal: World J Gastroenterol Date: 2016-08-07 Impact factor: 5.742

7. An old friend with new skills: Imiquimod as novel inhibitor of Hedgehog signaling in basal cell carcinoma.

Authors: Wolfgang Gruber; Anna-Maria Frischauf; Fritz Aberger
Journal: Oncoscience Date: 2014-09-16

8. Patched knockout mouse models of Basal cell carcinoma.

Authors: Frauke Nitzki; Marco Becker; Anke Frommhold; Walter Schulz-Schaeffer; Heidi Hahn
Journal: J Skin Cancer Date: 2012-09-13

9. Present status and upcoming prospects of hedgehog pathway inhibitors in small cell lung cancer therapy.

Authors: Syed Hassan Abbas Naqvi; Syed Hassan Shiraz Naqvi; Muhammad Yasin Bandukda; Syed Mumtaz Ali Naqvi
Journal: Infect Agent Cancer Date: 2013-05-22 Impact factor: 2.965

10. Hedgehog pathway inhibitors - current status and future prospects.

Authors: Asfandyar Sheikh; Arsalan Ahmad Alvi; Hafiz Muhammad Aslam; Abdul Haseeb
Journal: Infect Agent Cancer Date: 2012-11-01 Impact factor: 2.965