Literature DB >> 22652792

Mechanisms and emerging functions of DNA degradation in the epidermis.

Leopold Eckhart1, Heinz Fischer, Erwin Tschachler.   

Abstract

Degradation of DNA is involved in key processes maintaining the integrity of the epidermis such as the cornification of keratinocytes, the removal of damaged cells and the defense against potentially harmful microorganisms. Recent studies have characterized some of the molecular mechanisms and physiological functions of DNA degradation in the epidermis. Deoxyribonuclease (DNase)1L2 and TREX2 were identified as epidermis-specific DNases and DNase 2 was shown to be the predominant DNA-degrading enzyme on the surface of the skin. Here we review the latest insights into the DNA catabolism in the skin and discuss open questions pertaining to the molecular biology of epidermal DNA breakdown.

Entities:  

Mesh：

Substances：

Year:  2012        PMID： 22652792     DOI： 10.2741/4065

Source DB:  PubMed          Journal:  Front Biosci (Landmark Ed)        ISSN： 2768-6698


  9 in total

1.  Expression of human skin-specific genes defined by transcriptomics and antibody-based profiling.

Authors:  Per-Henrik D Edqvist; Linn Fagerberg; Björn M Hallström; Angelika Danielsson; Karolina Edlund; Mathias Uhlén; Fredrik Pontén
Journal:  J Histochem Cytochem       Date:  2014-11-19       Impact factor: 2.479

2.  Consistency of the proteome in primary human keratinocytes with respect to gender, age, and skin localization.

Authors:  Adrian Sprenger; Sebastian Weber; Mostafa Zarai; Rudolf Engelke; Juliana M Nascimento; Christine Gretzmeier; Martin Hilpert; Melanie Boerries; Cristina Has; Hauke Busch; Leena Bruckner-Tuderman; Jörn Dengjel
Journal:  Mol Cell Proteomics       Date:  2013-05-30       Impact factor: 5.911

3.  Optical characterization of epidermal cells and their relationship to DNA recovery from touch samples.

Authors:  Cristina E Stanciu; M Katherine Philpott; Ye Jin Kwon; Eduardo E Bustamante; Christopher J Ehrhardt
Journal:  F1000Res       Date:  2015-11-26

4.  Cytosolic RNA:DNA Duplexes Generated by Endogenous Reverse Transcriptase Activity as Autonomous Inducers of Skin Inflammation in Psoriasis.

Authors:  Jean-Pierre Molès; Anthony Griez; Jean-Jacques Guilhou; Céline Girard; Nicolas Nagot; Philippe Van de Perre; Pierre Dujols
Journal:  PLoS One       Date:  2017-01-17       Impact factor: 3.240

5.  Inactivation of DNase1L2 and DNase2 in keratinocytes suppresses DNA degradation during epidermal cornification and results in constitutive parakeratosis.

Authors:  Heinz Fischer; Maria Buchberger; Markus Napirei; Erwin Tschachler; Leopold Eckhart
Journal:  Sci Rep       Date:  2017-07-25       Impact factor: 4.379

6.  Survey of single-nucleotide polymorphisms in the gene encoding human deoxyribonuclease I-like 2 producing loss of function potentially implicated in the pathogenesis of parakeratosis.

Authors:  Misuzu Ueki; Haruo Takeshita; Natsuko Utsunomiya; Takanao Chino; Noritaka Oyama; Minoru Hasegawa; Kaori Kimura-Kataoka; Junko Fujihara; Reiko Iida; Toshihiro Yasuda
Journal:  PLoS One       Date:  2017-04-10       Impact factor: 3.240

7.  Serum TSLP is a potential biomarker of psoriasis vulgaris activity.

Authors:  Mohamed Ibrahim El-Ghareeb; Afaf Helmy; Sally Al Kazzaz; Hanan Samir
Journal:  Psoriasis (Auckl)       Date:  2019-07-30

8.  Application of a cost-effective DNA extraction protocol for screening transgenic and CRISPR-edited primary goat cells.

Authors:  Louhanna Pinheiro Rodrigues Teixeira; Francisco Eder de Moura Lopes; André Saraiva Leão Marcelo Antunes; Matheus Soares Alves; André Marrocos Miranda; Saul Gaudencio Neto; Leonardo Tondello Martins; Ana Cristina de Oliveira Monteiro Moreira; Kaio Cesar Simiano Tavares
Journal:  PLoS One       Date:  2020-09-18       Impact factor: 3.240

9.  DNA methylation at an enhancer of the three prime repair exonuclease 2 gene (TREX2) is linked to gene expression and survival in laryngeal cancer.

Authors:  Christoph Weigel; Jittiporn Chaisaingmongkol; Yassen Assenov; Christine Kuhmann; Volker Winkler; Irene Santi; Olga Bogatyrova; Simone Kaucher; Justo L Bermejo; Suet Y Leung; Tsun L Chan; Felix Lasitschka; Manfred H Bohrer; Alexander Marx; Roland Heyny-von Haußen; Christel Herold-Mende; Gerhard Dyckhoff; Petra Boukamp; Klaus W Delank; Karl Hörmann; Burkhard M Lippert; Gerald Baier; Andreas Dietz; Christopher C Oakes; Christoph Plass; Heiko Becher; Peter Schmezer; Heribert Ramroth; Odilia Popanda
Journal:  Clin Epigenetics       Date:  2019-05-03       Impact factor: 6.551
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.