Literature DB >> 2265243

Transforming growth factor beta downregulates interleukin-1 (IL-1)-induced IL-6 production by human monocytes.

T Musso1, I Espinoza-Delgado, K Pulkki, G L Gusella, D L Longo, L Varesio.   

Abstract

We investigated the effects of transforming growth factor beta (TGF beta) on the induction by interleukin-1 beta (IL-1 beta) of IL-6 in human monocytes. We found that IL-1 beta induced IL-6 messenger RNA expression in elutriated monocytes and IL-6 secretion in the supernatant. TGF beta did not induce IL-6. In contrast, TGF beta added to the culture inhibited, in a dose-dependent manner, the induction of IL-6 by IL-1 at the level of messenger RNA and bioactivity. These results show that IL-1 beta is able to stimulate IL-6 production by monocytes, TGF beta, by inhibiting this effect, may play an important role in regulating the IL-1-mediated components of the inflammatory response.

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Year:  1990        PMID： 2265243

Source DB:  PubMed          Journal:  Blood        ISSN： 0006-4971            Impact factor:   22.113


  21 in total

Review 1.  Cytokine-induced inflammation in the central nervous system revisited.

Authors:  J A Martiney; C Cuff; M Litwak; J Berman; C F Brosnan
Journal:  Neurochem Res       Date:  1998-03       Impact factor: 3.996

Review 2.  Roles of proinflammatory and anti-inflammatory cytokines in pathophysiology of bacterial meningitis and effect of adjunctive therapy.

Authors:  A M van Furth; J J Roord; R van Furth
Journal:  Infect Immun       Date:  1996-12       Impact factor: 3.441

3.  In vitro restoration of T cell responses in tuberculosis and augmentation of monocyte effector function against Mycobacterium tuberculosis by natural inhibitors of transforming growth factor beta.

Authors:  C S Hirsch; J J Ellner; R Blinkhorn; Z Toossi
Journal:  Proc Natl Acad Sci U S A       Date:  1997-04-15       Impact factor: 11.205

4.  Cross-modulation by transforming growth factor beta in human tuberculosis: suppression of antigen-driven blastogenesis and interferon gamma production.

Authors:  C S Hirsch; R Hussain; Z Toossi; G Dawood; F Shahid; J J Ellner
Journal:  Proc Natl Acad Sci U S A       Date:  1996-04-16       Impact factor: 11.205

5.  Induction of transforming growth factor beta 1 by purified protein derivative of Mycobacterium tuberculosis.

Authors:  Z Toossi; T G Young; L E Averill; B D Hamilton; H Shiratsuchi; J J Ellner
Journal:  Infect Immun       Date:  1995-01       Impact factor: 3.441

Review 6.  Regulation of the Immune Response by TGF-β: From Conception to Autoimmunity and Infection.

Authors:  Shomyseh Sanjabi; Soyoung A Oh; Ming O Li
Journal:  Cold Spring Harb Perspect Biol       Date:  2017-06-01       Impact factor: 10.005

7.  TGF-beta and IL-1 beta act in synergy to enhance IL-6 and IL-8 mRNA levels and IL-6 production by human retinal pigment epithelial cells.

Authors:  M C Kuppner; S McKillop-Smith; J V Forrester
Journal:  Immunology       Date:  1995-02       Impact factor: 7.397

8.  Transforming growth factor beta in normal human lung: preferential location in bronchial epithelial cells.

Authors:  A Magnan; I Frachon; B Rain; M Peuchmaur; G Monti; B Lenot; M Fattal; G Simonneau; P Galanaud; D Emilie
Journal:  Thorax       Date:  1994-08       Impact factor: 9.139

Review 9.  Interleukin-6 in clinical medicine.

Authors:  J Bauer; F Herrmann
Journal:  Ann Hematol       Date:  1991-06       Impact factor: 3.673

10.  Transforming growth factor beta is dispensable for the molecular orchestration of Th17 cell differentiation.

Authors:  Jyoti Das; Guangwen Ren; Liying Zhang; Arthur I Roberts; Xin Zhao; Alfred L M Bothwell; Luc Van Kaer; Yufang Shi; Gobardhan Das
Journal:  J Exp Med       Date:  2009-09-28       Impact factor: 14.307
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