OBJECTIVE: Recent studies give evidence that high frequency oscillations (HFOs) in the range between 80 Hz and 500 Hz in invasive recordings of epilepsy patients have the potential to serve as reliable markers of epileptogenicity. This study presents an algorithm for automatic HFO detection. METHODS: The presented HFO detector uses a radial basis function neural network. Input features of the detector were energy, line length and instantaneous frequency. Visual marked "ripple" HFOs (80-250 Hz) of 3 patients were used to train the neural network, and a further 8 patients served for the detector evaluation. RESULTS: Detector sensitivity and specificity were 49.1% and 36.3%. The linear and rank correlation between visual and automatic marked "ripple" HFO counts over the channels were significant for all recordings. A reference detector based on the line length achieved a sensitivity of 35.4% and a specificity of 46.8%. CONCLUSIONS: Automatic detections corresponded only partly to visual markings for single events but the relative distribution of brain regions displaying "ripple" HFO activity is reflected by the automated system. SIGNIFICANCE: The detector allows the automatic evaluation of brain areas with high HFO frequency, which is of high relevance for the demarcation of the epileptogenic zone.
OBJECTIVE: Recent studies give evidence that high frequency oscillations (HFOs) in the range between 80 Hz and 500 Hz in invasive recordings of epilepsypatients have the potential to serve as reliable markers of epileptogenicity. This study presents an algorithm for automatic HFO detection. METHODS: The presented HFO detector uses a radial basis function neural network. Input features of the detector were energy, line length and instantaneous frequency. Visual marked "ripple" HFOs (80-250 Hz) of 3 patients were used to train the neural network, and a further 8 patients served for the detector evaluation. RESULTS: Detector sensitivity and specificity were 49.1% and 36.3%. The linear and rank correlation between visual and automatic marked "ripple" HFO counts over the channels were significant for all recordings. A reference detector based on the line length achieved a sensitivity of 35.4% and a specificity of 46.8%. CONCLUSIONS: Automatic detections corresponded only partly to visual markings for single events but the relative distribution of brain regions displaying "ripple" HFO activity is reflected by the automated system. SIGNIFICANCE: The detector allows the automatic evaluation of brain areas with high HFO frequency, which is of high relevance for the demarcation of the epileptogenic zone.
Authors: Mark A Kramer; Lauren M Ostrowski; Daniel Y Song; Emily L Thorn; Sally M Stoyell; McKenna Parnes; Dhinakaran Chinappen; Grace Xiao; Uri T Eden; Kevin J Staley; Steven M Stufflebeam; Catherine J Chu Journal: Brain Date: 2019-05-01 Impact factor: 13.501
Authors: Su Liu; Candan Gurses; Zhiyi Sha; Michael M Quach; Altay Sencer; Nerses Bebek; Daniel J Curry; Sujit Prabhu; Sudhakar Tummala; Thomas R Henry; Nuri F Ince Journal: Brain Date: 2018-03-01 Impact factor: 13.501
Authors: Jan Schönberger; Anja Knopf; Kerstin Alexandra Klotz; Matthias Dümpelmann; Andreas Schulze-Bonhage; Julia Jacobs Journal: Brain Sci Date: 2021-04-24
Authors: Sergey Burnos; Peter Hilfiker; Oguzkan Sürücü; Felix Scholkmann; Niklaus Krayenbühl; Thomas Grunwald; Johannes Sarnthein Journal: PLoS One Date: 2014-04-10 Impact factor: 3.240
Authors: Yvonne Höller; Raoul Kutil; Lukas Klaffenböck; Aljoscha Thomschewski; Peter M Höller; Arne C Bathke; Julia Jacobs; Alexandra C Taylor; Raffaele Nardone; Eugen Trinka Journal: Front Hum Neurosci Date: 2015-10-20 Impact factor: 3.169