BACKGROUND: Factors affecting bone calcium deposition across pregnancy and lactation are not well characterized. OBJECTIVE: The impact of maternal age, calcium intake, race-ethnicity, and vitamin D status on the rate of bone calcium deposition (VO+) was assessed across pregnancy and lactation. DESIGN: Stable calcium isotopes were given to 46 women at pre- or early pregnancy (trimester 1), late pregnancy (trimester 3), and 3-10 wk postpartum. Three cohorts were included: 23 adolescents from Baltimore (MD), aged 16.5 ± 1.4 y (mean ± SD; Baltimore cohort); 13 adults from California, aged 29.5 ± 2.6 y (California cohort); and 10 adults from Brazil, aged 30.4 ± 4.0 y (Brazil cohort). The total exchangeable calcium pool, VO+, 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D [1,25(OH)₂D], parathyroid hormone, and calcium intake were evaluated. RESULTS: At trimester 3, inverse associations between 1,25(OH)₂D and VO+ were evident in the Baltimore (P = 0.059) and Brazil (P = 0.008) cohorts and in the whole group (P = 0.029); calcium intake was not a significant determinant of VO+ in any group during pregnancy. At postpartum, a significant positive association was evident between VO+ and calcium intake (P ≤ 0.002) and between VO+ and African ethnicity (P ≤ 0.004) in the whole group and within the Baltimore and Brazil cohorts. CONCLUSIONS: Elevated 1,25(OH)₂D was associated with decreased rates of bone calcium deposition during late pregnancy, a finding that was particularly evident in pregnant adolescents and adult women with low calcium intakes. Higher dietary calcium intakes and African ethnicity were associated with elevated rates of bone calcium deposition in the postpartum period.
BACKGROUND: Factors affecting bone calcium deposition across pregnancy and lactation are not well characterized. OBJECTIVE: The impact of maternal age, calcium intake, race-ethnicity, and vitamin D status on the rate of bone calcium deposition (VO+) was assessed across pregnancy and lactation. DESIGN: Stable calcium isotopes were given to 46 women at pre- or early pregnancy (trimester 1), late pregnancy (trimester 3), and 3-10 wk postpartum. Three cohorts were included: 23 adolescents from Baltimore (MD), aged 16.5 ± 1.4 y (mean ± SD; Baltimore cohort); 13 adults from California, aged 29.5 ± 2.6 y (California cohort); and 10 adults from Brazil, aged 30.4 ± 4.0 y (Brazil cohort). The total exchangeable calcium pool, VO+, 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D [1,25(OH)₂D], parathyroid hormone, and calcium intake were evaluated. RESULTS: At trimester 3, inverse associations between 1,25(OH)₂D and VO+ were evident in the Baltimore (P = 0.059) and Brazil (P = 0.008) cohorts and in the whole group (P = 0.029); calcium intake was not a significant determinant of VO+ in any group during pregnancy. At postpartum, a significant positive association was evident between VO+ and calcium intake (P ≤ 0.002) and between VO+ and African ethnicity (P ≤ 0.004) in the whole group and within the Baltimore and Brazil cohorts. CONCLUSIONS: Elevated 1,25(OH)₂D was associated with decreased rates of bone calcium deposition during late pregnancy, a finding that was particularly evident in pregnant adolescents and adult women with low calcium intakes. Higher dietary calcium intakes and African ethnicity were associated with elevated rates of bone calcium deposition in the postpartum period.
Authors: Jennifer Notkin Nielsen; Kimberly O O'Brien; Frank R Witter; Shih-Chen Chang; Jeri Mancini; Maureen Schulman Nathanson; Laura E Caulfield Journal: Am J Clin Nutr Date: 2006-07 Impact factor: 7.045
Authors: H Uemura; T Yasui; M Kiyokawa; A Kuwahara; H Ikawa; T Matsuzaki; M Maegawa; H Furumoto; M Irahara Journal: J Endocrinol Date: 2002-08 Impact factor: 4.286
Authors: Carmiña L Vargas Zapata; Carmen M Donangelo; Leslie R Woodhouse; Steven A Abrams; E Martin Spencer; Janet C King Journal: Am J Clin Nutr Date: 2004-08 Impact factor: 7.045
Authors: S A Abrams; J B Sidbury; J Muenzer; N V Esteban; N E Vieira; A L Yergey Journal: J Pediatr Gastroenterol Nutr Date: 1991-05 Impact factor: 2.839
Authors: Landing M A Jarjou; M Ann Laskey; Yankuba Sawo; Gail R Goldberg; Timothy J Cole; Ann Prentice Journal: Am J Clin Nutr Date: 2010-06-16 Impact factor: 7.045
Authors: Julia L Finkelstein; Eva K Pressman; Elizabeth M Cooper; Tera R Kent; Haim Y Bar; Kimberly O O'Brien Journal: Reprod Sci Date: 2014-11-02 Impact factor: 3.060
Authors: A Gu; R Sellamuthu; E Himes; P J Childress; L M Pelus; C M Orschell; M A Kacena Journal: J Musculoskelet Neuronal Interact Date: 2017-12-01 Impact factor: 2.041