PURPOSE: To assess prospectively the accuracy of diffusion-weighted magnetic resonance imaging (DWI) in differentiating between metastatic and benign axillary lymph nodes in patients with breast cancer. MATERIALS AND METHODS: In all, 215 patients with histologically proven breast cancer, prior to axillary dissection, underwent breast and axillary 1.5 T MRI. In 102 patients in whom at least one axillary lymph node with a short axis of 6 mm or more was found the apparent diffusion coefficient (ADC) was measured in one lymph node per patient by means of an echo planar, parallel imaging DWI sequence. Forty-three lymph nodes were finally included which, on histological examination, either contained a metastasis larger than 5 mm or were metastasis-free; nodes with metastases smaller than 5 mm were excluded. RESULTS: From histological examination, 19/43 lymph nodes had a metastasis at least 5 mm, while in 24/43 no malignant cells were found. The ADC values of the lymph nodes with metastases (mean: 0.878 × 10(-3) mm(2) /s; range: 0.30 -1.20) were significantly lower (P < 0.001) than those of the benign lymph nodes (mean: 1.494; range: 0.60 -2.50). Adopting a threshold value of 1.09 × 10(-3) mm(2) /s DWI resulted in 94.7% sensitivity, 91.7% specificity, and 93.0% accuracy in the identification of metastasis in this series of lymph nodes. CONCLUSION: From these preliminary data DWI seems a promising method in the differential diagnosis between metastatic and benign axillary lymph nodes in patients with breast cancer.
PURPOSE: To assess prospectively the accuracy of diffusion-weighted magnetic resonance imaging (DWI) in differentiating between metastatic and benign axillary lymph nodes in patients with breast cancer. MATERIALS AND METHODS: In all, 215 patients with histologically proven breast cancer, prior to axillary dissection, underwent breast and axillary 1.5 T MRI. In 102 patients in whom at least one axillary lymph node with a short axis of 6 mm or more was found the apparent diffusion coefficient (ADC) was measured in one lymph node per patient by means of an echo planar, parallel imaging DWI sequence. Forty-three lymph nodes were finally included which, on histological examination, either contained a metastasis larger than 5 mm or were metastasis-free; nodes with metastases smaller than 5 mm were excluded. RESULTS: From histological examination, 19/43 lymph nodes had a metastasis at least 5 mm, while in 24/43 no malignant cells were found. The ADC values of the lymph nodes with metastases (mean: 0.878 × 10(-3) mm(2) /s; range: 0.30 -1.20) were significantly lower (P < 0.001) than those of the benign lymph nodes (mean: 1.494; range: 0.60 -2.50). Adopting a threshold value of 1.09 × 10(-3) mm(2) /s DWI resulted in 94.7% sensitivity, 91.7% specificity, and 93.0% accuracy in the identification of metastasis in this series of lymph nodes. CONCLUSION: From these preliminary data DWI seems a promising method in the differential diagnosis between metastatic and benign axillary lymph nodes in patients with breast cancer.
Authors: Su Min Ha; Jung Min Chang; Soo-Yeon Kim; Su Hyun Lee; Eun Sil Kim; Yeon Soo Kim; Nariya Cho; Woo Kyung Moon Journal: Breast Cancer Res Treat Date: 2021-01-03 Impact factor: 4.872
Authors: Sileny N Han; Frédéric Amant; Katrijn Michielsen; Frederik De Keyzer; Steffen Fieuws; Kristel Van Calsteren; Raphaëla C Dresen; Mina Mhallem Gziri; Vincent Vandecaveye Journal: Eur Radiol Date: 2017-12-07 Impact factor: 5.315
Authors: Habib Rahbar; Jane L Conlin; Sana Parsian; Wendy B DeMartini; Sue Peacock; Constance D Lehman; Savannah C Partridge Journal: Acad Radiol Date: 2014-12-06 Impact factor: 3.173
Authors: E L Yuh; S Jain Palrecha; G M Lagemann; M Kliot; P R Weinstein; N M Barbaro; C T Chin Journal: AJNR Am J Neuroradiol Date: 2014-10-09 Impact factor: 3.825
Authors: V J L Kuijs; M Moossdorff; R J Schipper; R G H Beets-Tan; E M Heuts; K B M I Keymeulen; M L Smidt; M B I Lobbes Journal: Insights Imaging Date: 2015-03-24