OBJECTIVE: To investigate the potential cumulative impact of mild traumatic brain injury (MTBI) on postconcussive symptoms. PARTICIPANTS: A total of 224 active duty soldiers reporting MTBI within 1 year of testing. For 101, this MTBI was their only reported traumatic brain injury (TBI); 123 had sustained at least 1 additional MTBI during their lifetime. A No TBI control group (n = 224) was included for comparison. MAIN MEASURE: Self-report symptoms data via questionnaire. Within time since injury subgroups (≤3 months; Post-3 months), symptom endorsement (no symptoms, 1 or 2 symptoms, 3+ symptoms) among soldiers with 1 MTBI was compared with that of soldiers with 2 or more MTBIs. Injured soldiers' symptom endorsement was compared with that of soldiers who had not sustained a TBI. RESULTS: Among the recently injured (≤3 months), those with 2 or more MTBIs endorsed significantly more symptoms than those with 1 MTBI: 67% of soldiers with 2 or more MTBIs reported 3+ symptoms, versus 29% of One MTBI soldiers. Among Post-3 month soldiers, there were no significant differences between MTBI groups. Overall, soldiers with MTBI endorsed significantly more symptoms than those without TBI. CONCLUSION: Past experience of MTBI may be a risk factor for increased symptom difficulty for several months postinjury. Clinicians should ascertain lifetime history of brain injury when evaluating patients for MTBI.
OBJECTIVE: To investigate the potential cumulative impact of mild traumatic brain injury (MTBI) on postconcussive symptoms. PARTICIPANTS: A total of 224 active duty soldiers reporting MTBI within 1 year of testing. For 101, this MTBI was their only reported traumatic brain injury (TBI); 123 had sustained at least 1 additional MTBI during their lifetime. A No TBI control group (n = 224) was included for comparison. MAIN MEASURE: Self-report symptoms data via questionnaire. Within time since injury subgroups (≤3 months; Post-3 months), symptom endorsement (no symptoms, 1 or 2 symptoms, 3+ symptoms) among soldiers with 1 MTBI was compared with that of soldiers with 2 or more MTBIs. Injured soldiers' symptom endorsement was compared with that of soldiers who had not sustained a TBI. RESULTS: Among the recently injured (≤3 months), those with 2 or more MTBIs endorsed significantly more symptoms than those with 1 MTBI: 67% of soldiers with 2 or more MTBIs reported 3+ symptoms, versus 29% of One MTBI soldiers. Among Post-3 month soldiers, there were no significant differences between MTBI groups. Overall, soldiers with MTBI endorsed significantly more symptoms than those without TBI. CONCLUSION: Past experience of MTBI may be a risk factor for increased symptom difficulty for several months postinjury. Clinicians should ascertain lifetime history of brain injury when evaluating patients for MTBI.
Authors: Matthew W Reid; Kelly J Miller; Rael T Lange; Douglas B Cooper; David F Tate; Jason Bailie; Tracey A Brickell; Louis M French; Sarah Asmussen; Jan E Kennedy Journal: J Neurotrauma Date: 2014-10-24 Impact factor: 5.269
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Authors: Jiwon Ryu; Iren Horkayne-Szakaly; Leyan Xu; Olga Pletnikova; Francesco Leri; Charles Eberhart; Juan C Troncoso; Vassilis E Koliatsos Journal: Acta Neuropathol Commun Date: 2014-11-25 Impact factor: 7.801
Authors: Megan K Yee; Patricia A Janulewicz; Daniel R Seichepine; Kimberly A Sullivan; Susan P Proctor; Maxine H Krengel Journal: Brain Sci Date: 2017-07-09