Literature DB >> 22647376

Not all autophagy is equal.

Maria F Czyzyk-Krzeska1, Jarek Meller, David R Plas.   

Abstract

Autophagy is an important mechanism in cancer cell survival and tumor growth and plays both pro- and anti-oncogenic roles. However, the biochemical basis for these diverse functions is not well understood. Our work provides new evidence for the existence of two separate autophagic programs regulated in an opposite manner by the von Hippel-Lindau tumor suppressor (VHL). These programs, marked by differential requirements for LC3B vs. LC3C, play tumor-promoting and tumor-suppressing roles in renal cancer.

Entities:  

Keywords:  HIF; LC3B/LC3C; VHL; autophagy; renal cancer

Mesh：

Substances：

Year:  2012        PMID： 22647376      PMCID： PMC3429557          DOI： 10.4161/auto.20650

Source DB:  PubMed          Journal:  Autophagy        ISSN： 1554-8627            Impact factor:   16.016


  10 in total

Review 1.  Autophagy in health and disease: From molecular mechanisms to therapeutic target.

Authors:  Guang Lu; Yu Wang; Yin Shi; Zhe Zhang; Canhua Huang; Weifeng He; Chuang Wang; Han-Ming Shen
Journal:  MedComm (2020)       Date:  2022-07-10

2.  Tumor suppressor gene PDCD4 negatively regulates autophagy by inhibiting the expression of autophagy-related gene ATG5.

Authors:  Xingguo Song; Xia Zhang; Xiaoyan Wang; Faliang Zhu; Chun Guo; Qun Wang; Yongyu Shi; Jianing Wang; Youhai Chen; Lining Zhang
Journal:  Autophagy       Date:  2013-03-13       Impact factor: 16.016

Review 3.  Autophagy and Tubular Cell Death in the Kidney.

Authors:  Andrea Havasi; Zheng Dong
Journal:  Semin Nephrol       Date:  2016-05       Impact factor: 5.299

Review 4.  Autophagy in 5-Fluorouracil Therapy in Gastrointestinal Cancer: Trends and Challenges.

Authors:  Jia-Cheng Tang; Yi-Li Feng; Xiao Liang; Xiu-Jun Cai
Journal:  Chin Med J (Engl)       Date:  2016-02-20       Impact factor: 2.628

5.  MicroRNAs in clear cell renal cell carcinoma: biological functions and applications.

Authors:  Gianluca Aguiari
Journal:  J Kidney Cancer VHL       Date:  2015-08-23

6.  Human prion protein-induced autophagy flux governs neuron cell damage in primary neuron cells.

Authors:  Ji-Hong Moon; Ju-Hee Lee; Uddin Md Nazim; You-Jin Lee; Jae-Won Seol; Seong-Kug Eo; John-Hwa Lee; Sang-Youel Park
Journal:  Oncotarget       Date:  2016-05-24

7.  S100A4 promotes lung tumor development through β-catenin pathway-mediated autophagy inhibition.

Authors:  Shasha Hou; Tian Tian; Dianwen Qi; Kaiji Sun; Qi Yuan; Ziling Wang; Zhihai Qin; Zhenlong Wu; Zhinan Chen; Jinhua Zhang
Journal:  Cell Death Dis       Date:  2018-02-15       Impact factor: 8.469

8.  Rapamycin inhibits proliferation and induces autophagy in human neuroblastoma cells.

Authors:  Xiaokun Lin; Lei Han; Jialei Weng; Kelai Wang; Tongke Chen
Journal:  Biosci Rep       Date:  2018-11-30       Impact factor: 3.840

9.  Hinokitiol protects primary neuron cells against prion peptide-induced toxicity via autophagy flux regulated by hypoxia inducing factor-1.

Authors:  Ji-Hong Moon; Ju-Hee Lee; You-Jin Lee; Sang-Youel Park
Journal:  Oncotarget       Date:  2016-05-24

10.  EWS-FLI1 positively regulates autophagy by increasing ATG4B expression in Ewing sarcoma cells.

Authors:  Qunshan Lu; Yuankai Zhang; Liang Ma; Deqiang Li; Ming Li; Jianmin Li; Peilai Liu
Journal:  Int J Mol Med       Date:  2017-08-29       Impact factor: 4.101
  10 in total

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