Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Heterocycle-functional gramine analogues: solvent- and catalyst-free synthesis and their inhibition activities against cell proliferation.

Literature DB >> 22647218

Heterocycle-functional gramine analogues: solvent- and catalyst-free synthesis and their inhibition activities against cell proliferation.

Shaoyong Ke¹, Liqiao Shi, Xiufang Cao, Qingyu Yang, Ying Liang, Ziwen Yang.

Abstract

A series of novel gramine analogues were designed and synthesized via a convenient three-component reaction, and which were evaluated for their inhibition activities against cell proliferation. Their structures were confirmed by satisfactory spectra analyses mainly including (1)H NMR, and ESI-MS analyses. The preliminary assays indicated that some of the newly synthesized compounds displayed significantly good inhibition activities against human lung cancer (NCI-H460), hepatocellular liver carcinoma (HepG2), gastric cancer (SGC-7901 and BGC-823) cell lines compared with the control 5-Fluorouracil (5-FU), which might be developed as novel lead scaffold for potential anticancer agents.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 2012 PMID： 22647218 DOI： 10.1016/j.ejmech.2012.05.003

Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514

Keyword Cloud
Cited

7 in total

Review 1. α-Aminoazoles/azines: key reaction partners for multicomponent reactions.

Authors: Shah Imtiaz; Jahangir Ahmad War; Syqa Banoo; Sarfaraz Khan
Journal: RSC Adv Date: 2021-03-16 Impact factor: 3.361

Review 2. Naturally derived indole alkaloids targeting regulated cell death (RCD) for cancer therapy: from molecular mechanisms to potential therapeutic targets.

Authors: Rui Qin; Feng-Ming You; Qian Zhao; Xin Xie; Cheng Peng; Gu Zhan; Bo Han
Journal: J Hematol Oncol Date: 2022-09-14 Impact factor: 23.168

3. Steroidal[17,16-d]pyrimidines derived from dehydroepiandrosterone: A convenient synthesis, antiproliferation activity, structure-activity relationships, and role of heterocyclic moiety.

Authors: Shaoyong Ke; Liqiao Shi; Zhigang Zhang; Ziwen Yang
Journal: Sci Rep Date: 2017-03-14 Impact factor: 4.379

Heterocycle-functional gramine analogues: solvent- and catalyst-free synthesis and their inhibition activities against cell proliferation.

Review 1. α-Aminoazoles/azines: key reaction partners for multicomponent reactions.

Review 2. Naturally derived indole alkaloids targeting regulated cell death (RCD) for cancer therapy: from molecular mechanisms to potential therapeutic targets.

3. Steroidal[17,16-d]pyrimidines derived from dehydroepiandrosterone: A convenient synthesis, antiproliferation activity, structure-activity relationships, and role of heterocyclic moiety.

4. Nicotinamide-based diamides derivatives as potential cytotoxic agents: synthesis and biological evaluation.

5. Design, Synthesis, and Cytotoxic Activity of Novel Natural Arylsulfonamide-Inspired Molecules.

6. Diarylamine-Guided Carboxamide Derivatives: Synthesis, Biological Evaluation, and Potential Mechanism of Action.

7. Identification of adiponectin receptor agonist utilizing a fluorescence polarization based high throughput assay.