OBJECTIVE: The differential diagnosis between preterm and false labour remains one of the most challenging issues in perinatal medicine. AIM: To assess the prognostic importance of the selected biochemical markers in predicting preterm labour. MATERIAL AND METHODS: 74 patients hospitalized due to threatening preterm labour. 51 women gave birth prematurely; the remaining 23 were diagnosed with false labour. We used ELISA arrays to study 13 proteins: IGFBP-1, IGFBP-2, BDNF, L-Selectin, E-Selectin, ICAM-1, PECAM, VCAM-1, MIP-1 delta (MIP-1d) MIP-3β (MIP-3b), Eotaxin-1, Eotaxin-2, BLC. RESULTS: An increased risk of preterm labour should be expected when the serum concentration for: IGFBP-1 > 158.83 pg/ml (sens. 0.608, sp. 0.609, p < 0.0001); MIP-1d < 27.66 pg/ml (sens. 0.627, sp. 0.627, p = 0.021); BDNF >36.54 pg/ml (sens. 0.630, sp. 0.647, p = 0.002); BLC >25.46 pg/ml (sens. 0.588, sp. 0.609, p < 0.001); Eotaxin-1 >1.16 pg/ml (sens. 0.633, sp. 0.652). CONCLUSION: There have been reported statistically significant differences in serum concentrations of selected proteins in women with preterm labour and false labour.
OBJECTIVE: The differential diagnosis between preterm and false labour remains one of the most challenging issues in perinatal medicine. AIM: To assess the prognostic importance of the selected biochemical markers in predicting preterm labour. MATERIAL AND METHODS: 74 patients hospitalized due to threatening preterm labour. 51 women gave birth prematurely; the remaining 23 were diagnosed with false labour. We used ELISA arrays to study 13 proteins: IGFBP-1, IGFBP-2, BDNF, L-Selectin, E-Selectin, ICAM-1, PECAM, VCAM-1, MIP-1 delta (MIP-1d) MIP-3β (MIP-3b), Eotaxin-1, Eotaxin-2, BLC. RESULTS: An increased risk of preterm labour should be expected when the serum concentration for: IGFBP-1 > 158.83 pg/ml (sens. 0.608, sp. 0.609, p < 0.0001); MIP-1d < 27.66 pg/ml (sens. 0.627, sp. 0.627, p = 0.021); BDNF >36.54 pg/ml (sens. 0.630, sp. 0.647, p = 0.002); BLC >25.46 pg/ml (sens. 0.588, sp. 0.609, p < 0.001); Eotaxin-1 >1.16 pg/ml (sens. 0.633, sp. 0.652). CONCLUSION: There have been reported statistically significant differences in serum concentrations of selected proteins in women with preterm labour and false labour.
Authors: Barbara Lizewska; Joanna Teul; Pawel Kuc; Adam Lemancewicz; Karol Charkiewicz; Joanna Goscik; Marian Kacerovsky; Ramkumar Menon; Wojciech Miltyk; Piotr Laudanski Journal: Mediators Inflamm Date: 2018-02-15 Impact factor: 4.711
Authors: Kisoon Dan; Ji Eun Lee; Dohyun Han; Sun Min Kim; Subeen Hong; Hyeon Ji Kim; Kyo Hoon Park Journal: PLoS One Date: 2021-04-15 Impact factor: 3.240
Authors: Giovanni Monni; Luigi Atzori; Valentina Corda; Francesca Dessolis; Ambra Iuculano; K Joseph Hurt; Federica Murgia Journal: Front Med (Lausanne) Date: 2021-06-25
Authors: Piotr Laudanski; Adam Lemancewicz; Pawel Kuc; Karol Charkiewicz; Barbara Ramotowska; Malgorzata Kretowska; Elwira Jasinska; Grzegorz Raba; Katarzyna Karwasik-Kajszczarek; Janusz Kraczkowski; Tadeusz Laudanski Journal: Mediators Inflamm Date: 2014-04-28 Impact factor: 4.711