Literature DB >> 22646310

Human bone marrow-derived mesenchymal stem cells produced TGFbeta contributes to progression and metastasis of prostate cancer.

Huamao Ye1, Jiwen Cheng, Yuanjie Tang, Zhiyong Liu, Chuanliang Xu, Yan Liu, Yinghao Sun.   

Abstract

Human mesenchymal stem cells (hMSCs) play an important role in the development of human cancers. In the present study, we observed that hMSCs promoted human prostate cancer (PCa) cell PC-3 growth in vivo and in vitro. The conditional medium of hMSCs promoted the proliferation, migration, and invasion of PC-3 cells. The expression of MMP-2 and MMP-9 in PC-3 was upregulated by conditional medium of hMSCs. In addition, blocking tumor transformation factor beta (TGFβ) blunted the pro-oncogenic function of hMSCs. These results suggest that hMSCs may play a pro-oncogenic role in the growth of human prostate caner by producing TGFβ.

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Year:  2012        PMID： 22646310     DOI： 10.3109/07357907.2012.692171

Source DB:  PubMed          Journal:  Cancer Invest        ISSN： 0735-7907            Impact factor:   2.176


  26 in total

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Review 10.  Mesenchymal stem cells as a vector for the inflammatory prostate microenvironment.

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Journal:  Endocr Relat Cancer       Date:  2013-08-23       Impact factor: 5.678
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