Literature DB >> 22645167

A common ancestry for BAP1 and Uch37 regulators.

Luis Sanchez-Pulido1, Lesheng Kong, Chris P Ponting.   

Abstract

SUMMARY: To reveal how the polycomb repressive-deubiquitinase (PR-DUB) complex controls substrate selection specificity, we undertook a detailed computational sequence analysis of its components: additional sex combs like 1 (ASXL1) and BRCA1-associated protein 1 (BAP1) proteins. This led to the discovery of two previously unrecognized domains in ASXL1: a forkhead (winged-helix) DNA-binding domain and a deubiquitinase adaptor domain shared with two regulators of ubiquitin carboxyl-terminal hydrolase 37 (Uch37), namely adhesion regulating molecule 1 (ADRM1) and nuclear factor related to kappaB (NFRKB). Our analysis demonstrates a common ancestry for BAP1 and Uch37 regulators in PR-DUB, INO80 chromatin remodelling and proteosome complexes. CONTACT: luis.sanchezpulido@dpag.ox.ac.uk SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

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Year:  2012        PMID： 22645167     DOI： 10.1093/bioinformatics/bts319

Source DB:  PubMed          Journal:  Bioinformatics        ISSN： 1367-4803            Impact factor:   6.937


  31 in total

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2.  Structures of Rpn1 T1:Rad23 and hRpn13:hPLIC2 Reveal Distinct Binding Mechanisms between Substrate Receptors and Shuttle Factors of the Proteasome.

Authors:  Xiang Chen; Leah Randles; Ke Shi; Sergey G Tarasov; Hideki Aihara; Kylie J Walters
Journal:  Structure       Date:  2016-07-07       Impact factor: 5.006

3.  The stability of epigenetic factor ASXL1 is regulated through ubiquitination and USP7-mediated deubiquitination.

Authors:  D Inoue; K Nishimura; H Kozuka-Hata; M Oyama; T Kitamura
Journal:  Leukemia       Date:  2015-04-03       Impact factor: 11.528

4.  Impact of Losing hRpn13 Pru or UCHL5 on Proteasome Clearance of Ubiquitinated Proteins and RA190 Cytotoxicity.

Authors:  Vasty Osei-Amponsa; Vinidhra Sridharan; Mayank Tandon; Christine N Evans; Kimberly Klarmann; Kwong Tai Cheng; Justin Lack; Raj Chari; Kylie J Walters
Journal:  Mol Cell Biol       Date:  2020-08-28       Impact factor: 4.272

5.  Structural basis for the activation and inhibition of the UCH37 deubiquitylase.

Authors:  Ryan T Vander Linden; Casey W Hemmis; Benjamin Schmitt; Ada Ndoja; Frank G Whitby; Howard Robinson; Robert E Cohen; Tingting Yao; Christopher P Hill
Journal:  Mol Cell       Date:  2015-02-19       Impact factor: 17.970

Review 6.  The Role of Additional Sex Combs-Like Proteins in Cancer.

Authors:  Jean-Baptiste Micol; Omar Abdel-Wahab
Journal:  Cold Spring Harb Perspect Med       Date:  2016-10-03       Impact factor: 6.915

7.  Stabilization of an unusual salt bridge in ubiquitin by the extra C-terminal domain of the proteasome-associated deubiquitinase UCH37 as a mechanism of its exo specificity.

Authors:  Marie E Morrow; Myung-Il Kim; Judith A Ronau; Michael J Sheedlo; Rhiannon R White; Joseph Chaney; Lake N Paul; Markus A Lill; Katerina Artavanis-Tsakonas; Chittaranjan Das
Journal:  Biochemistry       Date:  2013-05-09       Impact factor: 3.162

8.  Proteasome-Bound UCH37/UCHL5 Debranches Ubiquitin Chains to Promote Degradation.

Authors:  Kirandeep K Deol; Sean O Crowe; Jiale Du; Heather A Bisbee; Robert G Guenette; Eric R Strieter
Journal:  Mol Cell       Date:  2020-11-05       Impact factor: 17.970

9.  The BAP1/ASXL2 Histone H2A Deubiquitinase Complex Regulates Cell Proliferation and Is Disrupted in Cancer.

Authors:  Salima Daou; Ian Hammond-Martel; Nazar Mashtalir; Haithem Barbour; Jessica Gagnon; Nicholas V G Iannantuono; Nadine Sen Nkwe; Alena Motorina; Helen Pak; Helen Yu; Hugo Wurtele; Eric Milot; Frédérick A Mallette; Michele Carbone; El Bachir Affar
Journal:  J Biol Chem       Date:  2015-09-28       Impact factor: 5.157

Review 10.  Meddling with Fate: The Proteasomal Deubiquitinating Enzymes.

Authors:  Stefanie A H de Poot; Geng Tian; Daniel Finley
Journal:  J Mol Biol       Date:  2017-10-05       Impact factor: 5.469
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