Literature DB >> 22645079

A Tn antigen binding lectin from Myrsine coriacea displays toxicity in human cancer cell lines.

Andrea Medeiros1, Nora Berois, Marcelo Incerti, Sylvie Bay, Laura Franco Fraguas, Eduardo Osinaga.   

Abstract

The Tn antigen (GalNAc-O-Ser/Thr) is one of the most specific human cancer-associated structures. In the present study we characterize the biochemical and functional properties of the Myrsine coriacea lectin (McL). We show that McL is an unusual high molecular weight highly glycosylated protein, which displays a strong Tn binding activity. The lectin exhibits in vitro inhibition of proliferation in the six cancer cell lines evaluated, in a dose-dependent manner (the strongest activity being against HT-29 and HeLa cells), whereas it does not exhibit toxicity against normal lymphocytes. McL could be exploited in the design of potential new tools for the diagnosis or treatment of cancer.

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Year:  2012        PMID： 22645079     DOI： 10.1007/s11418-012-0671-x

Source DB:  PubMed          Journal:  J Nat Med        ISSN： 1340-3443            Impact factor:   2.343


  47 in total

1.  In vitro influence of lectins and neoglycoconjugates on the growth of three human sarcoma cell lines.

Authors:  M Remmelink; F Darro; C Decaestecker; R De Decker; N V Bovin; M Gebhart; H Kaltner; H J Gabius; R Kiss; I Salmon; A Danguy
Journal:  J Cancer Res Clin Oncol       Date:  1999       Impact factor: 4.553

2.  A glycopeptide in complex with MHC class I uses the GalNAc residue as an anchor.

Authors:  Vasso Apostolopoulos; Elizabeth Yuriev; Paul A Ramsland; Jodie Halton; Carla Osinski; Wenjun Li; Magdalena Plebanski; Hans Paulsen; Ian F C McKenzie
Journal:  Proc Natl Acad Sci U S A       Date:  2003-12-01       Impact factor: 11.205

Review 3.  Lectins as bioactive plant proteins: a potential in cancer treatment.

Authors:  Elvira González De Mejía; Valentin I Prisecaru
Journal:  Crit Rev Food Sci Nutr       Date:  2005       Impact factor: 11.176

4.  Deglycosylation of glycoproteins by trifluoromethanesulfonic acid.

Authors:  A S Edge; C R Faltynek; L Hof; L E Reichert; P Weber
Journal:  Anal Biochem       Date:  1981-11-15       Impact factor: 3.365

5.  Core 3 synthase is down-regulated in colon carcinoma and profoundly suppresses the metastatic potential of carcinoma cells.

Authors:  Toshie Iwai; Takashi Kudo; Risa Kawamoto; Tomomi Kubota; Akira Togayachi; Toru Hiruma; Tomoko Okada; Toru Kawamoto; Kyoei Morozumi; Hisashi Narimatsu
Journal:  Proc Natl Acad Sci U S A       Date:  2005-03-08       Impact factor: 11.205

Review 6.  MUC1 and the MUCs: a family of human mucins with impact in cancer biology.

Authors:  Stephan E Baldus; Katja Engelmann; Franz-Georg Hanisch
Journal:  Crit Rev Clin Lab Sci       Date:  2004       Impact factor: 6.250

7.  A novel apoptotic pathway as defined by lectin cellular initiation.

Authors:  Brian Gastman; Kent Wang; Jie Han; Zhen-yu Zhu; Xiaojun Huang; Gui-Qiang Wang; Hannah Rabinowich; Elieser Gorelik
Journal:  Biochem Biophys Res Commun       Date:  2004-03-26       Impact factor: 3.575

8.  Differences in lectin reactivities of cellular glycoconjugates between primary human colorectal carcinomas and their metastases.

Authors:  I H Kellokumpu
Journal:  Cancer Res       Date:  1986-09       Impact factor: 12.701

9.  Isolation and characterization of an N-acetylgalactosamine specific lectin from Salvia sclarea seeds.

Authors:  V Piller; F Piller; J P Cartron
Journal:  J Biol Chem       Date:  1986-10-25       Impact factor: 5.157

Review 10.  Lectin of Concanavalin A as an anti-hepatoma therapeutic agent.

Authors:  Huan-Yao Lei; Chih-Peng Chang
Journal:  J Biomed Sci       Date:  2009-01-19       Impact factor: 8.410
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  3 in total

1.  Preclinical Studies of Granulysin-Based Anti-MUC1-Tn Immunotoxins as a New Antitumoral Treatment.

Authors:  Patricia Guerrero-Ochoa; Raquel Ibáñez-Pérez; Germán Berbegal-Pinilla; Diederich Aguilar; Isabel Marzo; Francisco Corzana; Martha Minjárez-Sáenz; Javier Macías-León; Blanca Conde; Javier Raso; Ramón Hurtado-Guerrero; Alberto Anel
Journal:  Biomedicines       Date:  2022-05-24

2.  Label-Free Proteome Analysis of Plasma from Patients with Breast Cancer: Stage-Specific Protein Expression.

Authors:  Marina Duarte Pinto Lobo; Frederico Bruno Mendes Batista Moreno; Gustavo Henrique Martins Ferreira Souza; Sara Maria Moreira Lima Verde; Renato de Azevedo Moreira; Ana Cristina de Oliveira Monteiro-Moreira
Journal:  Front Oncol       Date:  2017-02-02       Impact factor: 6.244

Review 3.  Plant Lectins Targeting O-Glycans at the Cell Surface as Tools for Cancer Diagnosis, Prognosis and Therapy.

Authors:  Guillaume Poiroux; Annick Barre; Els J M van Damme; Hervé Benoist; Pierre Rougé
Journal:  Int J Mol Sci       Date:  2017-06-09       Impact factor: 5.923
  3 in total

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