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Literature DB >> 22644884

Chemoselective ligation of sulfinic acids with aryl-nitroso compounds.

Abstract

Making a comeback: The inefficient condensation of sulfinic acid and aryl nitroso compounds has been transformed into a chemoselective process that converts sulfinic acid into stable cyclic sulfonamide analogues (see scheme). This ligation proceeds rapidly under aqueous conditions in high yield, and lays the groundwork for the development of sulfinic acid detection methods in biological systems.

Entities: Chemical Disease Gene Species

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Year: 2012 PMID： 22644884 PMCID： PMC3523331 DOI： 10.1002/anie.201201812

Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336

17 in total

1. Quantitation of protein sulfinic and sulfonic acid, irreversibly oxidized protein cysteine sites in cellular proteins.

Authors: Michael Hamann; Tiequan Zhang; Suzanne Hendrich; James A Thomas
Journal: Methods Enzymol Date: 2002 Impact factor: 1.600

2. Reversible oxidation of the active site cysteine of peroxiredoxins to cysteine sulfinic acid. Immunoblot detection with antibodies specific for the hyperoxidized cysteine-containing sequence.

Authors: Hyun Ae Woo; Sang Won Kang; Hyung Ki Kim; Kap-Seok Yang; Ho Zoon Chae; Sue Goo Rhee
Journal: J Biol Chem Date: 2003-10-14 Impact factor: 5.157

Chemoselective ligation of sulfinic acids with aryl-nitroso compounds.

1. Quantitation of protein sulfinic and sulfonic acid, irreversibly oxidized protein cysteine sites in cellular proteins.

2. Reversible oxidation of the active site cysteine of peroxiredoxins to cysteine sulfinic acid. Immunoblot detection with antibodies specific for the hyperoxidized cysteine-containing sequence.

Review 3. Expanding the functional diversity of proteins through cysteine oxidation.

4. Peroxide-dependent sulfenylation of the EGFR catalytic site enhances kinase activity.

Review 5. Chemical 'omics' approaches for understanding protein cysteine oxidation in biology.

Review 6. Reduction of cysteine sulfinic acid in eukaryotic, typical 2-Cys peroxiredoxins by sulfiredoxin.

Review 7. The sulfinic acid switch in proteins.

8. Colorimetric assay for methanesulfinic acid in biological samples.

9. ATP-dependent reduction of cysteine-sulphinic acid by S. cerevisiae sulphiredoxin.

10. Interior surface modification of bacteriophage MS2.

1. Harnessing Redox Cross-Reactivity To Profile Distinct Cysteine Modifications.

Review 2. Effects of ionizing radiation on biological molecules--mechanisms of damage and emerging methods of detection.

3. A Chemical Approach for the Detection of Protein Sulfinylation.

Review 4. Cysteine-mediated redox signaling: chemistry, biology, and tools for discovery.

Review 5. Chemical Probes for Redox Signaling and Oxidative Stress.

Review 6. The Expanding Landscape of the Thiol Redox Proteome.

Review 7. Proteomic approaches to quantify cysteine reversible modifications in aging and neurodegenerative diseases.

Review 8. Cysteine oxidative posttranslational modifications: emerging regulation in the cardiovascular system.

Review 9. Redox Signaling by Reactive Electrophiles and Oxidants.

10. Chasing cysteine oxidative modifications: proteomic tools for characterizing cysteine redox status.