Literature DB >> 22642477

Dynamic changes in serum angiopoietin-1, angiopoietin-2, and angiopoietin-2/angiopoietin-1 ratio in acute myocardial infarction patients treated with primary percutaneous coronary intervention.

Shaomin Chen1, Lijun Guo, Ming Cui, Lijie Sun, Lin Mi.   

Abstract

CONTEXT: Angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2) play divergent roles in myocardial ischemia and reperfusion injury.
OBJECTIVE: To investigate serum Ang-1 and Ang-2 levels in ST-segment elevation myocardial infarction (STEMI) patients treated with primary percutaneous coronary intervention (PCI).
METHODS: Serum Ang-1 and Ang-2 were measured in 85 STEMI patients in the first week after PCI.
RESULTS: Ang-1, Ang-2 and Ang-2/Ang-1 ratio (Ang-2/1) were all increased at admission, and had dynamic changes after PCI. Ang-2 and Ang-2/1 at admission and 2 h after PCI were positively correlated with peak cardiac troponin T levels.
CONCLUSION: The extent of myocardial damage may be linked to circulating Ang-2 and Ang-2/1.

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Year:  2012        PMID: 22642477     DOI: 10.3109/1354750X.2012.684152

Source DB:  PubMed          Journal:  Biomarkers        ISSN: 1354-750X            Impact factor:   2.658


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