H Park1, M H Green, M L Shaffer. 1. Department of Nutritional Sciences, College of Health and Human Development, Pennsylvania State University, University Park, PA, USA.
Abstract
BACKGROUND: Retinol-binding protein (RBP4) is an adipokine that may be important in type 2 diabetes. Previous studies have examined the association between serum RBP4 concentrations and clinical indices in patients with type 2 diabetes, although the results obtained have been inconsistent. We conducted a meta-analysis aiming to investigate the association between serum RBP4 concentrations and clinical indicators of diabetes, renal function, metabolic syndrome and obesity in subjects with type 2 diabetes. METHODS: MEDLINE, EMBASE and CINAHL databases were searched from 2005 through November 2011, and the search identified 21 clinical variables from seven studies (total n = 1406). For each variable, summary correlation coefficients (r(s) ) were estimated using a random-effects meta-analysis. RESULTS: None of the diabetes markers were correlated with serum RBP4 concentrations in subjects with type 2 diabetes, whereas all of the renal function markers and many metabolic syndrome markers were significantly correlated. Summary correlation coefficients and 95% confidence intervals (CIs) were -0.36 (95% CI = -0.51 to -0.18) for creatinine clearance, -0.39 (95% CI = -0.44 to -0.33) for estimated glomerular filtration rate and 0.53 (95% CI = 0.30-0.71) for creatinine concentration. In addition, plasma triglyceride concentrations (r(s) = 0.22; 95% CI = 0.11-0.32), plasma total cholesterol concentrations [r(s) = 0.14 (95% CI = 0.05-0.23)] and low-density lipoprotein cholesterol level (r(s) = 0.14; 95% CI = 0.02-0.25) were positively correlated with serum RBP4 concentrations. CONCLUSIONS: The results obtained in the present study suggest that serum RBP4 concentrations in patients with type 2 diabetes may be associated with diabetes-related renal dysfunction and imbalances in lipid metabolism.
BACKGROUND: Retinol-binding protein (RBP4) is an adipokine that may be important in type 2 diabetes. Previous studies have examined the association between serum RBP4 concentrations and clinical indices in patients with type 2 diabetes, although the results obtained have been inconsistent. We conducted a meta-analysis aiming to investigate the association between serum RBP4 concentrations and clinical indicators of diabetes, renal function, metabolic syndrome and obesity in subjects with type 2 diabetes. METHODS: MEDLINE, EMBASE and CINAHL databases were searched from 2005 through November 2011, and the search identified 21 clinical variables from seven studies (total n = 1406). For each variable, summary correlation coefficients (r(s) ) were estimated using a random-effects meta-analysis. RESULTS: None of the diabetes markers were correlated with serum RBP4 concentrations in subjects with type 2 diabetes, whereas all of the renal function markers and many metabolic syndrome markers were significantly correlated. Summary correlation coefficients and 95% confidence intervals (CIs) were -0.36 (95% CI = -0.51 to -0.18) for creatinine clearance, -0.39 (95% CI = -0.44 to -0.33) for estimated glomerular filtration rate and 0.53 (95% CI = 0.30-0.71) for creatinine concentration. In addition, plasma triglyceride concentrations (r(s) = 0.22; 95% CI = 0.11-0.32), plasma total cholesterol concentrations [r(s) = 0.14 (95% CI = 0.05-0.23)] and low-density lipoprotein cholesterol level (r(s) = 0.14; 95% CI = 0.02-0.25) were positively correlated with serum RBP4 concentrations. CONCLUSIONS: The results obtained in the present study suggest that serum RBP4 concentrations in patients with type 2 diabetes may be associated with diabetes-related renal dysfunction and imbalances in lipid metabolism.
Authors: Sherry A Tanumihardjo; Robert M Russell; Charles B Stephensen; Bryan M Gannon; Neal E Craft; Marjorie J Haskell; Georg Lietz; Kerry Schulze; Daniel J Raiten Journal: J Nutr Date: 2016-08-10 Impact factor: 4.798