Literature DB >> 22641430

Mechanism of cellular uptake of graphene oxide studied by surface-enhanced Raman spectroscopy.

Jie Huang1, Cheng Zong, He Shen, Min Liu, Biao Chen, Bin Ren, Zhijun Zhang.   

Abstract

The last few years have witnessed rapid development of biological and medical applications of graphene oxide (GO), such as drug/gene delivery, biosensing, and bioimaging. However, little is known about the cellular uptake mechanism and pathway of GO. In this work, surface-enhanced Raman scattering (SERS) spectroscopy is employed to investigate the cellular internalization of GO loaded with Au nanoparticles (NPs) by Ca Ski cells. The presence of Au NPs on the surface of GO enables detection of enhanced intrinsic Raman signals of GO inside the cell. The SERS results reveal that GO is distributed inhomogeneously inside the cell. Furthermore, internalization of Au-GO into Ca Ski cells is mainly via clathrin-mediated endocytosis, and is an energy-dependent process.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2012        PMID： 22641430     DOI： 10.1002/smll.201102743

Source DB:  PubMed          Journal:  Small        ISSN： 1613-6810            Impact factor:   13.281


  30 in total

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Journal:  Mikrochim Acta       Date:  2019-06-01       Impact factor: 5.833

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4.  Graphene oxide (GO)-based nanosheets with combined chemo/photothermal/photodynamic therapy to overcome gastric cancer (GC) paclitaxel resistance by reducing mitochondria-derived adenosine-triphosphate (ATP).

Authors:  Weihong Guo; Zhian Chen; Xiaoli Feng; Guodong Shen; Huilin Huang; Yanrui Liang; Bingxia Zhao; Guoxin Li; Yanfeng Hu
Journal:  J Nanobiotechnology       Date:  2021-05-19       Impact factor: 10.435

Review 5.  Graphene materials as 2D non-viral gene transfer vector platforms.

Authors:  M Vincent; I de Lázaro; K Kostarelos
Journal:  Gene Ther       Date:  2016-11-22       Impact factor: 5.250

6.  Surface-enhanced Raman scattering analysis of urine from deceased donors as a prognostic tool for kidney transplant outcome.

Authors:  Jingmao Chi; Yiwei Ma; Francis L Weng; Heather Thiessen-Philbrook; Chirag R Parikh; Henry Du
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Review 7.  Toxicology of graphene-based nanomaterials.

Authors:  Gaurav Lalwani; Michael D'Agati; Amit Mahmud Khan; Balaji Sitharaman
Journal:  Adv Drug Deliv Rev       Date:  2016-05-03       Impact factor: 15.470

Review 8.  Graphene-based nanomaterials for bioimaging.

Authors:  Jing Lin; Xiaoyuan Chen; Peng Huang
Journal:  Adv Drug Deliv Rev       Date:  2016-05-24       Impact factor: 15.470

9.  Surface Oxidation of Graphene Oxide Determines Membrane Damage, Lipid Peroxidation, and Cytotoxicity in Macrophages in a Pulmonary Toxicity Model.

Authors:  Ruibin Li; Linda M Guiney; Chong Hyun Chang; Nikhita D Mansukhani; Zhaoxia Ji; Xiang Wang; Yu-Pei Liao; Wen Jiang; Bingbing Sun; Mark C Hersam; Andre E Nel; Tian Xia
Journal:  ACS Nano       Date:  2018-01-22       Impact factor: 15.881

10.  Endocytosis Is a Key Mode of Interaction between Extracellular β-Amyloid and the Cell Membrane.

Authors:  Jing-Ming Shi; Li Zhu; Xi Lan; Duan-Wei Zhao; Yong-Jun He; Zheng-Qi Sun; Di Wu; Hai-Yun Li
Journal:  Biophys J       Date:  2020-08-15       Impact factor: 4.033
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